KEYS to Succeed: Cognitive and Academic Intervention Program for Children and Adolescents Surviving Cancer
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Wechsler Intelligence Scale for Children - Fourth Edition Integrated
Study Overview
Brief Summary
The study will examine whether school liaison services and home-based parental tutoring can help with academic difficulties of paediatric brain tumour survivors who received cranial spinal radiation and have returned to school. Forty-five patients will participate in the project. All patients will receive psychology liaison services to link resources at the hospital with those in the community. Patients will participate in one of two tutoring programs designed to directly or indirectly improve math skills over 12 weeks. Weekly phone calls will be used to support parents using the program. Patients will be tested before, immediately after, and six months following each tutoring program to assess growth in mathematics and working memory abilities.
Detailed Description
Paediatric brain tumour survivors who receive cranial spinal radiation have learning problems, particularly in mathematics and working memory. Working memory is often described as a "mental workspace" where relevant information is held in mind and processed. Working memory is important in mathematics for holding in mind relevant information and carrying out steps necessary to solve problems.
This study will examine whether school liaison support and home-based parental tutoring can help address the academic difficulties of paediatric brain tumour survivors who have received cranial spinal radiation and who have returned to their community school. Forty five patients will participate in the project. First, all patients will receive psychology liaison services to link resources at the hospital with those in the community in order to provide information regarding the effects of pediatric cancer on learning and facilitate the implementation of appropriate assistive technology and remediation programs. Patients will then participant in one of two tutoring programs over the course of a 12 week period. One group of patients will participate in a program that addresses working memory with the intent of indirectly helping with mathematics skills. This program will be delivered over the internet. Another group of patients will participate in a program using a work book to directly help improve mathematics skills. Weekly phone calls will be used to support parents in doing the program. Patients will be tested before, immediately after, and six months following each tutoring program to assess growth in mathematics and working memory abilities. The two intervention programs will be compared to a waitlist control group that receives only the liaison service (including academic support through weekly phone calls over the 12 weeks).
The findings from this study will provide evidence about the type of intervention that is most effective at helping paediatric brain tumour survivors improve their mathematics skills and working memory ability.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 6 Years to 17 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Has been diagnosed with a brain tumour and treated with cranial radiation
- •Is between 1 and 10 years following diagnosis
- •Has English as his or her native language or has had at least two years of schooling in English
- •Is between the ages of 6 and 17
- •Less than a Grade 8 equivalent math score
Exclusion Criteria
- •Is younger than 6 years or older than 17 years of age
- •Is receiving palliative care
Arms & Interventions
Math + Liaison Service
To help with mathematics, participants will be assigned to a workbook based version of the JUMP Math program which will be completed at home with a parent. This intervention focuses on mental math skills. In addition all participants will receive the liaison service program.
Intervention: Liaison Services (Behavioral)
Working Memory + Liaison Service
To help with working memory, participants will be assigned to Cogmed, a game-like computer exercise focusing on improving working memory. In addition all participants will receive the liaison service program.
Intervention: Cogmed (Behavioral)
Working Memory + Liaison Service
To help with working memory, participants will be assigned to Cogmed, a game-like computer exercise focusing on improving working memory. In addition all participants will receive the liaison service program.
Intervention: Liaison Services (Behavioral)
Liaison Services
Participants in this group will only receive the liaison service program for 12 weeks before being assigned to one of the intervention groups.
Intervention: Liaison Services (Behavioral)
Math + Liaison Service
To help with mathematics, participants will be assigned to a workbook based version of the JUMP Math program which will be completed at home with a parent. This intervention focuses on mental math skills. In addition all participants will receive the liaison service program.
Intervention: Jump Math (Behavioral)
Outcomes
Primary Outcomes
Wechsler Intelligence Scale for Children - Fourth Edition Integrated
Time Frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up
A measure of verbal and visual working memory
Woodcock Johnson Academic-Third Edition
Time Frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up
A measure of math Fluency, applied math problems, and qualitative concepts
Behaviour Rating Inventory of Executive Function-Parent Version
Time Frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up
A measure of executive functioning
Wide Range Assessment of Memory and Learning - Second Edition
Time Frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up
A measure of verbal and visual working memory
Automated Working Memory Assessment
Time Frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up
A measure of verbal and visual working memory
Connors' Continuous Performance Test-Second Edition
Time Frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up
A measure of sustained attention
Monitoring Basic Skills Progress
Time Frame: Pre-intervention, 12 weeks after intervention and 6 months follow-up
A measure of mathematics
Secondary Outcomes
- SAM(Pre-intervention, 12 weeks after intervention and 6 months follow-up)
- California Verbal Learning Test, Children's Version(Pre-intervention, 12 weeks after intervention and 6 months follow-up)
- Delis-Kaplan Executive Function System(Pre-intervention, 12 weeks after intervention and 6 months follow-up)
- CANTAB(Pre-intervention, 12 weeks after intervention and 6 months follow-up)
- Wechsler Abbreviated Scale of Intelligence - Second Edition(Pre-intervention, 12 weeks after intervention and 6 months follow-up)
- Wide Range Assessment of Memory and Learning - Second Edition(Pre-intervention, 12 weeks after intervention and 6 months follow-up)
Investigators
Donald Mabbott
Program Head, Neurosciences & Mental Health
The Hospital for Sick Children