KEYS to Succeed: Cognitive and Academic Intervention Program for Children and Adolescents Surviving Cancer

Not Applicable

Completed

• Conditions: Childhood Brain Tumor
• Interventions: Behavioral: Liaison Services; Behavioral: Cogmed; Behavioral: Jump Math

• Registration Number: NCT02573441
• Lead Sponsor: The Hospital for Sick Children

Brief Summary

The study will examine whether school liaison services and home-based parental tutoring can help with academic difficulties of paediatric brain tumour survivors who received cranial spinal radiation and have returned to school. Forty-five patients will participate in the project. All patients will receive psychology liaison services to link resources at the hospital with those in the community. Patients will participate in one of two tutoring programs designed to directly or indirectly improve math skills over 12 weeks. Weekly phone calls will be used to support parents using the program. Patients will be tested before, immediately after, and six months following each tutoring program to assess growth in mathematics and working memory abilities.

Detailed Description

Paediatric brain tumour survivors who receive cranial spinal radiation have learning problems, particularly in mathematics and working memory. Working memory is often described as a "mental workspace" where relevant information is held in mind and processed. Working memory is important in mathematics for holding in mind relevant information and carrying out steps necessary to solve problems.

This study will examine whether school liaison support and home-based parental tutoring can help address the academic difficulties of paediatric brain tumour survivors who have received cranial spinal radiation and who have returned to their community school. Forty five patients will participate in the project. First, all patients will receive psychology liaison services to link resources at the hospital with those in the community in order to provide information regarding the effects of pediatric cancer on learning and facilitate the implementation of appropriate assistive technology and remediation programs. Patients will then participant in one of two tutoring programs over the course of a 12 week period. One group of patients will participate in a program that addresses working memory with the intent of indirectly helping with mathematics skills. This program will be delivered over the internet. Another group of patients will participate in a program using a work book to directly help improve mathematics skills. Weekly phone calls will be used to support parents in doing the program. Patients will be tested before, immediately after, and six months following each tutoring program to assess growth in mathematics and working memory abilities. The two intervention programs will be compared to a waitlist control group that receives only the liaison service (including academic support through weekly phone calls over the 12 weeks).

The findings from this study will provide evidence about the type of intervention that is most effective at helping paediatric brain tumour survivors improve their mathematics skills and working memory ability.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2015-10
• Study First Submitted: 2015-10-07
• Study First Submitted QC: 2015-10-07
• Study First Posted: 2015-10-09
• Primary Completion: 2018-05
• Study Completion: 2018-05
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-12
• Last Update Posted: 2024-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Has been diagnosed with a brain tumour and treated with cranial radiation
• Is between 1 and 10 years following diagnosis
• Has English as his or her native language or has had at least two years of schooling in English
• Is between the ages of 6 and 17
• Less than a Grade 8 equivalent math score

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Exclusion Criteria

• Is younger than 6 years or older than 17 years of age
• Is receiving palliative care

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Liaison Services	Liaison Services	Participants in this group will only receive the liaison service program for 12 weeks before being assigned to one of the intervention groups.
Working Memory + Liaison Service	Cogmed	To help with working memory, participants will be assigned to Cogmed, a game-like computer exercise focusing on improving working memory. In addition all participants will receive the liaison service program.
Working Memory + Liaison Service	Liaison Services	To help with working memory, participants will be assigned to Cogmed, a game-like computer exercise focusing on improving working memory. In addition all participants will receive the liaison service program.
Math + Liaison Service	Jump Math	To help with mathematics, participants will be assigned to a workbook based version of the JUMP Math program which will be completed at home with a parent. This intervention focuses on mental math skills. In addition all participants will receive the liaison service program.
Math + Liaison Service	Liaison Services	To help with mathematics, participants will be assigned to a workbook based version of the JUMP Math program which will be completed at home with a parent. This intervention focuses on mental math skills. In addition all participants will receive the liaison service program.

Primary Outcome Measures

Name	Time	Method
Wechsler Intelligence Scale for Children - Fourth Edition Integrated	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of verbal and visual working memory
Woodcock Johnson Academic-Third Edition	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of math Fluency, applied math problems, and qualitative concepts
Behaviour Rating Inventory of Executive Function-Parent Version	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of executive functioning
Wide Range Assessment of Memory and Learning - Second Edition	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of verbal and visual working memory
Automated Working Memory Assessment	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of verbal and visual working memory
Connors' Continuous Performance Test-Second Edition	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of sustained attention
Monitoring Basic Skills Progress	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of mathematics

Secondary Outcome Measures

Name	Time	Method
SAM	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of participants attitude towards math
California Verbal Learning Test, Children's Version	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of verbal learning and memory
Delis-Kaplan Executive Function System	Pre-intervention, 12 weeks after intervention and 6 months follow-up	Measures of processing speed and switching attention
CANTAB	Pre-intervention, 12 weeks after intervention and 6 months follow-up	Measures of processing speed
Wechsler Abbreviated Scale of Intelligence - Second Edition	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of vocabulary and abstract visual reasoning
Wide Range Assessment of Memory and Learning - Second Edition	Pre-intervention, 12 weeks after intervention and 6 months follow-up	A measure of visual learning and memory

Trial Locations

Locations (1)

Hospital for Sick Children; 🇨🇦 Toronto, Ontario, Canada