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临床试验/NCT06569641
NCT06569641尚未招募不适用

Cardiac Surgery Recovery in Infants Assessed Using Neoneur Feeding System

Neoneur LLC0 个研究点目标入组 35 人开始时间: 2024年9月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
Neoneur LLC
入组人数
35
主要终点
To test the validity in use of feeding parameters to measure recovery progress for infants with complex CHD

研究概览

简要总结

A prospective non-randomized longitudinal design of 30-40 infants from initiation of oral feeding until discharge to track feeding changes as a potential indicator of surgical recovery.

详细描述

Safe oral feeding is a challenge for infants born with complex congenital heart disease (CHD). These infants are likely to require tube-assisted feeding at the initiation of enteral feeding and struggle to transition to full oral feeding. Infant post-surgery recovery includes a safe transition to oral feeding without respiratory risk. Neoneur Feeding System, consists of a novel hand-held, mobile phone application, and a cloud based computation, which innovatively measures patterns of oral cavity pressure synchronized with respiration, providing a quantitative assessment of feeding patterns. Yet there has been no quantitative means of measuring this recovery process. The concept of post-surgical recovery model is not new. The adult literature is replete with physiologic and behavioral indicators of recovery. More recently Roy and colleagues introduced a recovery model for post-surgical CHD children to adults using a component metrics of physiologic parameters. We are proposing to develop an infant specific recovery model using feeding patterns using data generated by the Neoneur device. The model, using the lens of behavioral organization, will include feeding measurements from initiation of oral feeding to discharge.

This study will evaluate the association between feeding recovery and clinical assessment of infant behaviors as measured in a brief survey to assess irritability, ability to be soothed, alertness, non-nutritive sucking, and muscle tone. Forty infants will be recruited from the PCICU-CSD at MUSC to capture thirty usable infant sets of Neoneur data from the PCICU-CSD at MUSC. This data will be assessed using the Neoneur Feeding System to create a model of feeding recovery.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
1 Day 至 50 Days(Child)
性别
All
接受健康志愿者

入选标准

  • Complex congenital heart disease requiring cardiac surgery during first month of life
  • Gestational age>=35 weeks at birth

排除标准

  • No other major non-cardiac congenital anomalies,
  • No history of major neurologic insult
  • Not listed for a heart transplant,
  • Not intubated for >4 weeks post-surgery,
  • Not trisomy 13, 18, and 21
  • No cleft lip/palate.

结局指标

主要结局

To test the validity in use of feeding parameters to measure recovery progress for infants with complex CHD

时间窗: 12 months

A comparison of feeding patterns (oral cavity pressure changes in suck and swallow, and respiratory patterns) and changes as an infant recovers and determination if there is a greater than 60% concordance with behavioral survey measuring recovery.

次要结局

  • Comparison of Neoneur Feeding system measurements seen in post surgical infants, to match clinical observation of suck, swallow, and breathing during oral feeding.(12 months)

研究者

发起方
Neoneur LLC
申办方类型
Industry
责任方
Sponsor

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