Advanced Myocardial Deformation Echocardiography for the Athlete's Heart Evaluation: Functional and Mechanistic Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 191
- 试验地点
- 1
- 主要终点
- Multilayer (= epi- and endocardial) left ventricular global longitudinal strain using Speckle-tracking echocardiography
研究概览
简要总结
Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling. The lower range of normal values of lLeft ventricle systolic ejection fraction (LVEF) and global longitudinal strain (GLS) in athletes makes it difficult to differentiate changes related to adaptive remodelling or indicative of early cardiomyopathy.
This study aims to improve the assessment of athletes' hearts by identifying echocardiographic phenotypes, using a speckle tracking including temporal deformation pattern and layer-specific approach, and to define predictive factors of subtle LV systolic dysfunction and of mechanical LV abnormalities.
详细描述
Healthy male athletes belonging to local clubs, who underwent a pre-participation medical evaluation at the University Hospital of Nancy between 2013 and 2020, will be screened. Clinical, echocardiographic and cardiopulmonary exercise testing data will be compared to a group of healthy men from the STANISLAS cohort. Subtle LV dysfunction will be defined by a GLS <17.5%.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •athletes who underwent a pre-participation medical evaluation in the Nancy University Hospital between January 1st, 2013, and January 1st, 2020
排除标准
- •female athletes,
- •athletes followed for cardiomyopathy
- •athletes who did not have transthoracic echocardiography (TTE) performed.
结局指标
主要结局
Multilayer (= epi- and endocardial) left ventricular global longitudinal strain using Speckle-tracking echocardiography
时间窗: Baseline
expressed in %
次要结局
- BMI(baseline)
- Height(baseline)
- Weight(baseline)
- Age(Baseline)
- Heart rate(baseline)
- Type of practiced sport(baseline)
- Inter ventricular septum diameter(baseline)
- Left ventricle indexed mass(baseline)
- Cardiac Index(baseline)
- Maximal E-wave velocity and Maximal A-wave velocity(baseline)
- Left atrium End-systolic volume(baseline)
- Left ventricular Ejection Fraction(baseline)
- PST (postsystolic thickening) assessed by Speckle-tracking echocardiography(baseline)
- left ventricular End-diastolic volume(baseline)
- left ventricular global longitudinal strain (peak G) assessed by Speckle-tracking echocardiography(baseline)
- PSI (pre stretch index) assessed by Speckle-tracking echocardiography(baseline)
- Peak VO2(baseline)
研究者
PACE Nathalie
Doctor of Medicine (MD) in Cardiology
Central Hospital, Nancy, France