Myocardial Mechanics in Athlete's Heart

Completed

• Conditions: Athlete Heart

• Registration Number: NCT05543525
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling. The lower range of normal values of lLeft ventricle systolic ejection fraction (LVEF) and global longitudinal strain (GLS) in athletes makes it difficult to differentiate changes related to adaptive remodelling or indicative of early cardiomyopathy.

This study aims to improve the assessment of athletes' hearts by identifying echocardiographic phenotypes, using a speckle tracking including temporal deformation pattern and layer-specific approach, and to define predictive factors of subtle LV systolic dysfunction and of mechanical LV abnormalities.

Detailed Description

Healthy male athletes belonging to local clubs, who underwent a pre-participation medical evaluation at the University Hospital of Nancy between 2013 and 2020, will be screened. Clinical, echocardiographic and cardiopulmonary exercise testing data will be compared to a group of healthy men from the STANISLAS cohort. Subtle LV dysfunction will be defined by a GLS \<17.5%.

Study Timeline

• Study Start: 2021-07-01
• Primary Completion: 2022-01-01
• Study Completion: 2022-01-01
• Study First Submitted: 2022-09-08
• Study First Submitted QC: 2022-09-15
• Study First Posted: 2022-09-16
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-29
• Last Update Posted: 2023-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 191

Inclusion Criteria

• athletes who underwent a pre-participation medical evaluation in the Nancy University Hospital between January 1st, 2013, and January 1st, 2020

Exclusion Criteria

• female athletes,
• athletes followed for cardiomyopathy
• athletes who did not have transthoracic echocardiography (TTE) performed.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Multilayer (= epi- and endocardial) left ventricular global longitudinal strain using Speckle-tracking echocardiography	Baseline	expressed in %

Secondary Outcome Measures

Name	Time	Method
Height	baseline	meter
Weight	baseline	meter
Age	Baseline	years
Heart rate	baseline	bpm
Type of practiced sport	baseline	soccer, basketball, handball
Inter ventricular septum diameter	baseline	mm
Left ventricle indexed mass	baseline	g/m²
Maximal E-wave velocity and Maximal A-wave velocity	baseline	m/s
Left atrium End-systolic volume	baseline	ml/m²
Left ventricular Ejection Fraction	baseline	using simpson's biplane method, expressed in %
PST (postsystolic thickening) assessed by Speckle-tracking echocardiography	baseline	expressed in %
left ventricular End-diastolic volume	baseline	ml
left ventricular global longitudinal strain (peak G) assessed by Speckle-tracking echocardiography	baseline	expressed in %
PSI (pre stretch index) assessed by Speckle-tracking echocardiography	baseline	expressed in %
BMI	baseline	kg/m²
Cardiac Index	baseline	ml/min/m²
Peak VO2	baseline	L/min

Trial Locations

Locations (1)

Chru Nancy; 🇫🇷 Nancy, France