Serum Calcium to Phosphorus (Ca/P) Ratio to Define Disorders of Ca-P Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 606
- 试验地点
- 1
- 主要终点
- Serum Calcium to Phosphorus ratio
研究概览
简要总结
BACKGROUND: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder. The Ca/P ratio is an accurate tool to differentiate patients with PHPT (>3.5 if Ca and P are expressed in mg/dl) from healthy subjects. The reliability of this index is based on the fact that serum Ca and P are inversely related together. However, other disorders of the Ca-P metabolism, such as hypophosphoremia (HypoP) not related to PHPT, might also impair the Ca/P ratio.
OBJECTIVE: To validate the accuracy of Ca/P ratio in the diagnosis of Ca-P metabolism disorders, including also patients with documented HypoP not related to PHPT.
METHODS: A single-center, retrospective, case-control study will be carried out.
Biochemical measurements will include parathormone (PTH), vitamin D, serum Ca and P, serum albumin and creatinine.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with diagnosis of primary hyperparathyroidism
- •HIV-infected patients with reduced phosphorus but normal calcium
- •subjects with normal Calcium-Phosphorus metabolism
- •Exclusion criteria for both cases and controls will be:
- •age younger than 18 or older than 90 years
- •severe renal and liver diseases (i.e. glomerular filtration rate (GFR) <30 ml/min)
- •hyperparathyroidism secondary to Vitamin D deficiency
- •active metabolic bone disease (e.g. Paget's disease of the bone, osteomalacia, rickets, etc)
- •any type of cancer
- •malnutrition
- •severe obesity (BMI > 40 kg/m2)
- •a history of gastrointestinal malabsorption
- •sarcoidosis
- •hypercortisolism
- •diabetes insipidus
- •hyperthyroidism
- •pseudohypoparathyroidism
- •familial hypocalciuric hypercalcemia (FHH)
- •treatment with steroids, active forms of vitamin D (calcitriol, ergocalciferol, etc), thiazides, phosphate binders, lithium, cinacalcet, bisphosphonates, and denosumab.
排除标准
- 未提供
结局指标
主要结局
Serum Calcium to Phosphorus ratio
时间窗: Assessed only once at the diagnosis (from January 2005 to January 2018)
Calculated formula (serum calcium to serum phosphorus ratio)
次要结局
- Serum Calcium(Assessed only once at the diagnosis (from January 2005 to January 2018))
- Serum Phosphorus(Assessed only once at the diagnosis (from January 2005 to January 2018))
- Serum Parathormone(Assessed only once at the diagnosis (from January 2005 to January 2018))
研究者
Vincenzo Rochira
Professor
Azienda Ospedaliero-Universitaria di Modena