Comparison of GAP, ILD-GAP, and CPI in Idiopathic Pulmonary Fibrosis (IPF) and Hypersensitivity Pneumonitis (HP)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 143
- Locations
- 1
- Primary Endpoint
- Prognostic performance of the Gender-Age-Physiology (GAP) Index, Interstitial Lung Disease-GAP (ILD-GAP) Index, and Composite Physiologic Index (CPI) in predicting overall survival
Study Overview
Brief Summary
The goal of this retrospective observational study is to evaluate and compare the prognostic value of GAP, ILD-GAP, and CPI scoring systems in patients diagnosed with interstitial lung diseases (ILDs), specifically Idiopathic Pulmonary Fibrosis (IPF), fibrotic Hypersensitivity Pneumonitis, and non-fibrotic Hypersensitivity Pneumonitis.
The main questions it aims to answer are:
- Can GAP, ILD-GAP, and CPI scores accurately predict prognosis in IPF, fibrotic HP, and non-fibrotic HP patients?
- Are there differences in prognostic performance of these models across different ILD subtypes?
Researchers will compare the prognostic utility of GAP, ILD-GAP, and CPI scores between IPF, fibrotic HP, and non-fibrotic HP groups to see if one scoring system offers superior predictive power.
Participants:
- Adults aged ≥18 years
- Diagnosed between October 2011 and October 2021 at the University of Health Sciences Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital
- 143 patients in total (IPF: 45, fibrotic HP: 26, non-fibrotic HP: 72)
Participants' data will include:
- Clinical and demographic characteristics
- Symptom duration
- Radiologic imaging findings
- Pulmonary function test (PFT) results
- Bronchoalveolar lavage (BAL) findings
- Histopathological diagnoses
Scoring systems will be calculated using standardized formulas as follows:
- GAP (Gender, Age, Physiology)
- ILD-GAP (modified GAP for CTD-ILDs)
- CPI (Composite Physiologic Index = 91 - [0.65 × %DLCO] - [0.53 × %FVC] + [0.34 × %FEV1])
Detailed Description
This is a retrospective observational study designed to evaluate and compare the prognostic performance of three widely used scoring systems-Gender-Age-Physiology (GAP) Index, Interstitial Lung Disease-GAP (ILD-GAP) Index, and Composite Physiologic Index (CPI)-in patients diagnosed with interstitial lung diseases (ILDs). The study focuses specifically on three ILD subtypes: Idiopathic Pulmonary Fibrosis (IPF), fibrotic Hypersensitivity Pneumonitis (HP), and non-fibrotic HP.
The primary objective is to determine whether GAP, ILD-GAP, and CPI scores can accurately predict overall survival across these patient groups. A secondary aim is to compare the prognostic performance of the scoring systems to explore whether one model provides superior predictive value in specific ILD subtypes.
The study cohort includes adult patients (≥18 years) who were diagnosed between October 2011 and October 2021 at the University of Health Sciences Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital. A total of 143 patients were identified and included: 45 patients with IPF, 26 with fibrotic HP, and 72 with non-fibrotic HP.
Data collected for each patient include clinical and demographic characteristics, duration of symptoms, high-resolution computed tomography (HRCT) findings, pulmonary function test (PFT) results, bronchoalveolar lavage (BAL) findings, and histopathological diagnoses where available. The final diagnosis in each case was established through multidisciplinary team (MDT) discussions and/or histopathological confirmation.
The scoring systems were calculated using standardized formulas:
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •40 patients diagnosed with IPF based on clinical features, laboratory findings, thoracic HRCT results, and/or histopathological confirmation, as determined by a multidisciplinary team discussion.
- •40 patients diagnosed with Fibrotic Hypersensitivity Pneumonitis based on clinical features, laboratory findings, and thoracic HRCT results, confirmed in a multidisciplinary team discussion.
- •40 patients diagnosed with Non-Fibrotic Hypersensitivity Pneumonitis based on clinical features, laboratory findings, and thoracic HRCT results, confirmed in a multidisciplinary team discussion.
- •Male and female patients over 18 years of age.
Exclusion Criteria
- •Patients under 18 years of age
Outcomes
Primary Outcomes
Prognostic performance of the Gender-Age-Physiology (GAP) Index, Interstitial Lung Disease-GAP (ILD-GAP) Index, and Composite Physiologic Index (CPI) in predicting overall survival
Time Frame: Using data collected between October 2011 and October 2021
Prognostic performance of GAP, ILD-GAP, and CPI scoring systems in predicting overall survival among patients with Idiopathic Pulmonary Fibrosis (IPF), fibrotic Hypersensitivity Pneumonitis, and non-fibrotic Hypersensitivity Pneumonitis.
Secondary Outcomes
- Association between clinical parameters and survival across ILD subgroups(Using data collected between October 2011 and October 2021)
- Impact of CPI score increase on mortality risk(Using data collected between October 2011 and October 2021)
- Effect of GAP stage, gender, and CTD status on survival(Using data collected between October 2011 and October 2021)
- Comparison of prognostic performance (AUC) of GAP, ILD-GAP, and CPI across ILD subtypes(At baseline scoring and during follow-up (using data collected between October 2011 and October 2021))
Investigators
ERDOGAN CETINKAYA
Prof. Dr.
Saglik Bilimleri Universitesi