Effects of Laser Therapy on Muscle Function in COPD Patients

Not Applicable

• Conditions: Chronic Obstructive Pulmonary Disease; Fatigue
• Interventions: Other: Laser therapy; Other: Placebo laser therapy

• Registration Number: NCT01448564
• Lead Sponsor: Eduardo Foschini Miranda

Brief Summary

Light-emitting diodes (LEDs) have been used to minimize muscle fatigue in athletes and healthy subjects. Patients with chronic obstructive pulmonary disease (COPD) are susceptible to early muscle fatigue. The objective of this study is to assess the acute effects of LEDs on muscle function, exercise capacity, and cardiorespiratory responses during isometric and dynamic exercise in patients with COPD. This study will assess 30 patients with moderate to severe obstruction (FEV1 ≤ 70% predicted). Isometric and dynamic protocols will be conducted in two visits each, for a total of four visits a week a part. First, a venous blood sample will be taken from the patients. The isometric protocol will start with the determination of the maximum voluntary isometric contraction (MIVC) to determine the workload (60% of MIVC) for the isometric endurance test (IET). Patients will be randomized to receive either the placebo or LED application. Immediately after finishing this procedure, the patients will carry out the IET until the limit of tolerance or until a 20% fall of strength is observed. After the test, another blood sample will be taken. In the other visit (one week later), the same order of procedures will be performed, except with the opposite (LED or placebo). For the dynamic protocol, the same procedures described above will be followed except with the maximal incremental cycle ergometer test used instead of the IET. The electromyography will be recorded during the isometric and dynamic protocols. Differences in muscle function, exercise capacity, and cardiorespiratory responses between the LED and placebo applications will be analyzed. The therapeutic effects of LED could minimize muscle fatigue in patients with COPD by increasing exercise tolerance.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-10-03
• Study First Submitted QC: 2011-10-06
• Study First Posted: 2011-10-07
• Study Start: 2012-06
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-03
• Last Update Posted: 2013-09-04
• Primary Completion: 2013-12
• Study Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• 35 patients will be selected (see sample calculation in Section 6) who have moderate to severe obstruction (FEV1 ≤ 70% predicted) and stable disease, as suggested by the absence of changes in medication in the last 4 weeks.

Exclusion Criteria

• Ischemic heart disease, recent surgery, neuro-muscular or orthopedic that limit the performance of the protocol.
• Patients will only be included in the study after signing the consent form.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Laser therapy	Laser therapy	Recently has been using the LED, known by its acronym in English LED (Light Emitting Diode), devices that are light-emitting non-coherent and monochromatic, having a longer wavelength (± 10 - 30 nm) compared to lasers. The difference between the fundamental radiation emitted by a laser and an LED is the coherence of the beam.
Placebo Laser therapy	Placebo laser therapy	-

Primary Outcome Measures

Name	Time	Method
Analysis of the recovery time for the isometric and dynamic protocol	Measures muscular endurance will be compared after a period of 1 week.

Secondary Outcome Measures

Name	Time	Method
Analysis of lactate levels and the activity of CK and C-reactive protein (CRP).	Measures blood will be compared after a period of 1 week.

Trial Locations

Locations (1)

University Nove de Julho; 🇧🇷 São Paulo, Brazil