Effects of Chronic Exercise Training and Vitamin C Supplementation on Physiological Changes and Symptoms in Allergic Rhinitis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Changes from baseline in rhinitis symptoms
研究概览
简要总结
- Moderate exercise training decrease cytokine response and rhinitis symptoms in patients with allergic rhinitis
- Moderate exercise training combined with vitamin C supplementation decrease cytokine response and rhinitis symptoms in patients with allergic rhinitis
- Moderate exercise training combined with vitamin C supplementation has more beneficial effects than moderate exercise training alone for decreasing cytokine response and rhinitis symptoms in patients with allergic rhinitis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria included patients with allergic rhinitis who had a clinical history of persistent rhinitis, and had positive skin prick test (wheal diameter ≥ 3 mm) to house dust mite (D. pteronyssinus).
排除标准
- •Subjects with known asthma, chronic rhinosinusitis, hypertension or cardiovascular diseases were excluded.
结局指标
主要结局
Changes from baseline in rhinitis symptoms
时间窗: Baseline, week 8
Nasal symptoms will be assessed using a rhinitis symptom score questionnaire. The subjects will be asked to score symptoms of persistent allergic rhinitis; nasal congestion, itching, sneezing, and rhinorrhea before and after each exercise protocol. The score ranged from 0 to 3 points (0 = none, 1 = mild, 2 = moderate, 3 = severe).
Changes from baseline in cytokine
时间窗: baseline, week 8
The cytokines IL-2, IL-4, and IL-13 in blood and nasal secretion will be determined by using the flow cytometry technique (Scavuzzo MC. et al., 2003). Data will be acquired using a flow cytometer (BD FACSCalibur Flow Cytometer, USA) and analyzed by FlowcytomixTM Pro software (eBioscience, USA.).
次要结局
- Changes from baseline in pulmonary function(Baseline, Week 8)
- Changes from baseline in peak nasal inspiratory flow(Baseline, Week 8)
- Changes from baseline in cardiorespiratory fitness (VO2max)(Baseline, Week 8)
- Changes from baseline in nasal blood flow(Baseline, week 8)
研究者
Assoc. Prof. Dr.Daroonwan Suksom
Faculty of Sports Science
Chulalongkorn University