The uninfected Ixodes scapularis human tick challenge model
Recruiting
- Conditions
- Tick borne diseases10004018
- Registration Number
- NL-OMON51305
- Lead Sponsor
- Amsterdam UMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 11
Inclusion Criteria
> 18 years;
Negative Borrelia VlsE1/pepC10 ELISA.
Exclusion Criteria
Known history of tick bites;
Positive Borrelia serology (VlsE1/PepC10 ELISA);
Known history or current suspicion on any tick-borne disease
Red meat allergy (both medically confirmed and self-reported);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study endpoint is the tick feeding phenotype; tick weight after<br /><br>feeding, tick attachment rate, days of attachment, tick survival rate and<br /><br>molting success. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary parameters are signs of an immune response in the host; itch,<br /><br>redness, or other signs of a (local) immune response (blood and skin biopsies). </p><br>