Study of Rubella Immunity. Response to Vaccination of Subjects With Very Low, Equivocal or Undetectable Titers of Rubella Virus Antibodies
Not Applicable
Completed
- Conditions
- Pregnancy
- Interventions
- Biological: Determination of Anti-Rubella Antibody, E1
- Registration Number
- NCT02934295
- Lead Sponsor
- Hopital Foch
- Brief Summary
The aim of the research is to study humoral and cellular immunity in pregnant women for who the level of rubella virus antibodies is weakly positive, equivocal or negative with the usual laboratory technique.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 192
Inclusion Criteria
- Women over 18
- Rubella serology negative, ambiguous or weakly positive during a first prenatal consultation and for which the second determination of the immunity anti rubella is necessary after 18 weeks of pregnancy
- Accepting the rubella vaccination after the childbirth;
- Accepting a blood test, during a postnatal consultation, 6 in 8 weeks after vaccination, to verify their immunity towards the virus of the rubella.
- Affiliated to a social security scheme
- Having given a written consent
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Exclusion Criteria
- Rubella contracted since the first serology realized during the first prenatal consultation
- Autoimmune pathologies
- Intolerance / allergy known about a previous vaccination whatever it is
- Immunosuppression (HIV, transplants)
- Injection of multivalent immunoglobulins (except anti-D)
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Pregnant women Determination of Anti-Rubella Antibody, E1 -
- Primary Outcome Measures
Name Time Method Level of Anti-Rubella Antibody, E1 8 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Hôpital Foch
🇫🇷Suresnes, France
Hôpital Antoine-Béclère
🇫🇷Clamart, France