Study of UGT1A1*27 gene polymorphism for irinotecan therapy
Not Applicable
- Conditions
- ung cancer
- Registration Number
- JPRN-UMIN000006164
- Lead Sponsor
- ung Oncology Group in Kyusyu
- Brief Summary
Fifty patients were enrolled, with 48 patients determined eligible. UGT1A1 polymorphisms 28/28, 6/6, 28/-, 6/-, -/-, observed 0 (0%), 1(2%), 1(2%), 7(15%), 17(35%), and 22(46%), respectively. UGT1A1*27 were examined in 9 patients including one ineligible patient, however, no polymorphisms were found.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
1) interstitial pneumonia in chest X-ray 2) with active infection 3) with active the other malignancies 4) pregnancy or possible pregnancy 5) mental diesease difficult to attend the study 6) high fever >= 38 degree 7) severe complication: myocardial infarction within 3 months, uncontrolled angina pectoris, heart failure, diabetes mellitus, hypertension 8) diarrhea 9) paralysis of intestine or ileus
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method