In older adults (60+ years) at risk for depression, can sertraline and/or omega-3 fatty acids compared with a placebo, reduce or prevent depressive symptoms, incidence of new cases of depression and/or cognitive decline.

niversity of Sydney0 sites205 target enrollmentJanuary 12, 2010

Overview

No summary available.

Registry

who.int

Start Date

January 12, 2010

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

•To be eligible participants must:
•\- Have provided written informed consent before any trial procedures are undertaken
•\- Be aged 60 years or older, and
•\- have a lifetime history of depressive symptoms (defined as a K\-10 score ranging from 16 to 29\) meaning that participants included in the trial will be at greater risk of depression.

•Participants will be excluded if they: \- Have a history of stroke/other serious cerebro or cardiovascular illness, neurological, psychiatric or neurodegenerative disease or other significant illness; Show clinically relevant levels of depression on the Patient Health Questionnaire (PHQ\-9\) at the time of screening or, receive a diagnosis of depression based on the Structured Clinical Interview for DSM\-IV\-TR Axis I Disorders (SCID\-I) at the time of completing the medical assessment; Are suicidal at the time of screening or at the time of completing the medical assessment; Show abnormal liver function or; Are currently taking anti\-depressant medications and it is deemed unadvisable by the trial psychiatrist to cease these medications for the period of the trial.