PICASSO: Prophylactic IncCsional Antibiotics in Skin Surgery trial. Can infiltrating antibiotics reduce the rate of wound infection?
Phase 4
Completed
- Conditions
- wound infectiongraft failureSurgery - Surgical techniquesCancer - Non melanoma skin cancerCancer - Malignant melanoma
- Registration Number
- ACTRN12616000364471
- Lead Sponsor
- A/Prof (Hon) Jon Mathy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 2340
Inclusion Criteria
All patients waitlisted for surgical management of skin lesions following specialist evaluation at the CMDHB Skin Cancer Centre and whom are able to provide consent independently.
Exclusion Criteria
History of allergy to FLUCLOXACILLIN or CLINDAMYCIN.
Pre-operative administration of antibiotics.
Inability to return for follow up.
Inability to consent independently.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Wound infection: all surgical sites will be assessed at 5-10 days and 3-4 week time points postoperatively and graded for signs of infection as per the standardized scoring system adopted from Griego et al. <br>Griego R, Zitelli J. Intra-incisional prophylactic antibiotics for dermatologic surgery. Archives of Dermatology. 1998;134(6):688-92.[Once at 5 days post surgery and once at 3 weeks post surgery.]
- Secondary Outcome Measures
Name Time Method Graft take: all surgical sites closed with a skin graft will be assessed at 5-10 days and 3-4 week time points postoperatively and graded for percentage graft take. A transparent plastic film with a printed grid 1cm x 1cm will be used to estimate the total size of the graft and the percentage of graft take. Photographs will be taken for re-assessment by another observer.[Once at 5 days post surgery and once at 3 weeks post surgery.]