The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe Pneumonia
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Rate of changes in empirical antibiotic therapy due to broad microbiological diagnostic
研究概览
简要总结
The purpose of the study is to determine if the clinical course of pneumonia is more severe when both, bacterial and viral pathogens are find as possible causative agent and how does it affect treatment.
详细描述
Basic demographic data of the patients (age, gender), data on concomitant diseases and epidemiological circumstances will be collected
Severity of illness will be assessed by APACHE II (at day 1) and SOFA (at day 1,2,3 and 7) scoring system
Following laboratory tests will be performed at day 1, 2,3 and 7.:
- blood count analysis
- differential blood count
- C- reactive protein, procalcitonin
- glucose, urea, potassium, sodium, chloride, magnesium, creatinine, bilirubin, protein, albumin, alkaline phosphatase, aspartate aminotransferase, alanine transaminase, gamma-glutamyl transpeptidase , alpha-amylase, lipase, creatine kinase, lactate dehydrogenase, myoglobin
- arterial blood gas analysis
- tests of hemostasis.
Additional 2 mL of blood will be taken at day 1 and day 21 (or later), due to paired serologic testing
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of
- •severe community acquired pneumonia or
- •severe hospital acquired pneumonia or
- •ventilator--associated pneumonia
排除标准
- •antibiotic treatment of actual episode of pneumonia for more than 24 hours
结局指标
主要结局
Rate of changes in empirical antibiotic therapy due to broad microbiological diagnostic
时间窗: each patient will be assessed at enrollment and follow-up for 2 months
次要结局
未报告次要终点
研究者
Primoz Karner
MD
University Medical Centre Ljubljana