ACTRN12606000155594
Active, Not Recruiting
N/A
A continuous positive airway pressure (CPAP) weaning trial to determine the most efficient method in weaning babies less than 30 weeks gestational age OFF CPAP.
Dr David Todd0 sites200 target enrollmentMay 3, 2006
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Babies who are on constant continuous positive airway pressure (CPAP) support need to have the CPAP weaned in order to allow the babies to breathe without support.
- Sponsor
- Dr David Todd
- Enrollment
- 200
- Status
- Active, Not Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.All babies \<30 weeks gestational age 2\.On CPAP for \>24 hours 3\.Babies either extubated to CPAP or as a primary treatment for respiratory distress Criteria for commencing weaning: Babies must have all of the following for the past 12 hours:\- 1\.CPAP \<6 cm H2O 2\.Oxygen requirement less than 26% and not increasing 3\.RR less than 60 4\.No significant chest recession 5\.Less than 3 episodes of mild self reverting apnoeas and/or bradycardias and/or desaturations in 1 hour for the previous 6 hours 6\.Average saturation above 87% most of the time and/or transcutaneous (TcPO2\)/arterial PaO2 \>50 mm Hg. 7\.Tolerates nose rests well during nursing cares 8\.Not treated for patent ductus arteriosus (PDA) or sepsis Criteria for failed trial OFF” at least 2 of the following:\- 1\.Increase work of breathing (Intercostal recession and accessory muscles contributing for respiration) with RR \>75 for \>1 hour 2\.Increased apnoeas and/or bradycardias and/or desaturations \>2 in previous 1 hour 3\.Major apnoea or bradycardia requiring more sustained stimulation/ resuscitation 4\.Increased O2 requirement \>25% with average saturation \<85% and/or TcPO2/PaO2 \<45mmHg 5\.pH of \<7\.2 6\.PaCO2 of \> 65 mmHg. The babies will be put back on CPAP if failed trial OFF” CPAP. If a baby has a major apnoea and/or bradycardia requiring resuscitation they may require intubation and ventilation.
Exclusion Criteria
- •1\. If congenital respiratory abnormality including central and anatomical.
Outcomes
Primary Outcomes
Not specified
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