Comparison of Non-invasive Methods of Lung Ventilation in Patients With Respiratory Failure in the Postoperative Period After Cardiac Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Failure
- Sponsor
- Petrovsky National Research Centre of Surgery
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- PaO2/FiO2 more than 300
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Comparison of the effectiveness of three methods of non-invasive ventilation in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery
Detailed Description
The study includes the comparison of the three methods of non-invasive ventilation: non-invasive mask ventilation, high-flow oxygen therapy through a nasal cannula (high-flow nasal oxygenation) and non-invasive ventilation with a helmet in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery. It assumes 90 randomized patients:30 patients in three study groups male and female aged 30 to 60 years of age inclusive, with mild or moderate respiratory failure.The study will be randomized, single-center, prospective.
Investigators
Darya Ryabova, research worker
Russian national research center of surgery named after academian B. V. Petrovsky
Petrovsky National Research Centre of Surgery
Eligibility Criteria
Inclusion Criteria
- •Age from 30 years to 60 years inclusive
- •Decreased oxygenation function of the lungs (SpO2 less than 90%, PaO2/FiO2 less than 300, BH less than 25 per minute)
- •By data CT/x-ray examination of hypoventilation zones (pneumonia, atelectasis)
- •Consent the patient to participate in this study
Exclusion Criteria
- •Tracheal intubation, absence of independent breathing
- •Unstable hemodynamics or hemodynamically significant rhythm disturbances
- •Acute violation of the cerebral blood supply
- •Shocks of various etiologies
- •Impossibility provide respiratory protection , high risk of aspiration
- •Lack of productive contact with the patient
- •Patient's refusal to participate in this study
Outcomes
Primary Outcomes
PaO2/FiO2 more than 300
Time Frame: hospitalisation period, an average of 1 week
Comparison of PaO2/FiO2 before/after research
Secondary Outcomes
- maximum inspiratory volume(hospitalisation period, an average of 1 week)
- arterial blood oxygenation level(hospitalisation period, an average of 1 week)