Comparison of Non-invasive Methods of Lung Ventilation in Patients With Respiratory Failure in the Postoperative Period After Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- PaO2/FiO2 more than 300
研究概览
简要总结
Comparison of the effectiveness of three methods of non-invasive ventilation in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery
详细描述
The study includes the comparison of the three methods of non-invasive ventilation: non-invasive mask ventilation, high-flow oxygen therapy through a nasal cannula (high-flow nasal oxygenation) and non-invasive ventilation with a helmet in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery. It assumes 90 randomized patients:30 patients in three study groups male and female aged 30 to 60 years of age inclusive, with mild or moderate respiratory failure.The study will be randomized, single-center, prospective.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age from 30 years to 60 years inclusive
- •Decreased oxygenation function of the lungs (SpO2 less than 90%, PaO2/FiO2 less than 300, BH less than 25 per minute)
- •By data CT/x-ray examination of hypoventilation zones (pneumonia, atelectasis)
- •Consent the patient to participate in this study
排除标准
- •Tracheal intubation, absence of independent breathing
- •Unstable hemodynamics or hemodynamically significant rhythm disturbances
- •Acute violation of the cerebral blood supply
- •Shocks of various etiologies
- •Impossibility provide respiratory protection , high risk of aspiration
- •Lack of productive contact with the patient
- •Patient's refusal to participate in this study
结局指标
主要结局
PaO2/FiO2 more than 300
时间窗: hospitalisation period, an average of 1 week
Comparison of PaO2/FiO2 before/after research
次要结局
- maximum inspiratory volume(hospitalisation period, an average of 1 week)
- arterial blood oxygenation level(hospitalisation period, an average of 1 week)
研究者
Darya Ryabova, research worker
Russian national research center of surgery named after academian B. V. Petrovsky
Petrovsky National Research Centre of Surgery