Effect of Slope Time in PCV Mode on Mechanical Power Calculation and Oxygenation in Covid-19 ARDS Patients.

• Conditions: COVID-19 Pneumonia; COVID-19 Acute Respiratory Distress Syndrome
• Interventions: Other: mechanical ventilation

• Registration Number: NCT05474300
• Lead Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Brief Summary

The investigators are planning to investigate the effect of each 5% slope time change on mechanical power and SPO2 of the patients with Covid 19 ARDS diagnosis which are on mechanical ventilation PCV mode support.

Detailed Description

In this study, with inspiration/expiration 1:2 and 1:1 time ratios in pressure controlled ventilation mode with different slope times mechanical power will be calculated in covid ARDS patients. In this way, the effect of every 5% slope time change in PCV on mechanical power and SPO2 will be investigated.

Study Timeline

• Study Start: 2022-06-06
• Study First Submitted: 2022-07-25
• Study First Submitted QC: 2022-07-25
• Study First Posted: 2022-07-26
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-01
• Last Update Posted: 2022-08-03
• Primary Completion: 2022-08-06
• Study Completion: 2022-08-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• adult patients with Covid-19 Acute Respiratory Distress Syndrome (ARDS) diagnosis
• intubated Covid-19 ARDS patients
• Covid-19 ARDS patients on mechanical ventilator support

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Exclusion Criteria

• heart failure disease
• Chronic Obstructive Pulmonary Disease (COPD)
• hemodynamically unstable patients
• pregnancy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Covid-19 ARDS patients on PCV mode	mechanical ventilation	No Intervention

Primary Outcome Measures

Name	Time	Method
mechanical power	100 minutes	Mechanical power calculated by Becher et al. comprehensive formula (MPpcv(slope)) and Trinkle, Christine A et al lineer model mechanical power formula (MPLM).

Trial Locations

Locations (1)

Bakırköy Dr sadi konuk Education hospital; 🇹🇷 Istanbul, Turkey