NCT00298376
Unknown
Not Applicable
Oral Tolerance in Cow's Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora
ConditionsCow's Milk Allergy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cow's Milk Allergy
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 50
- Locations
- 1
- Last Updated
- 19 years ago
Overview
Brief Summary
This study aims to determine if there is a link between cow's milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others.
Cow's milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge.
Number and function of regulatory T cells and microflora composition are measured at the same time.
Allergic infants are compared to age matched control group.
Investigators
Eligibility Criteria
Inclusion Criteria
- •male or female, age before 6 month, cow's milk allergy with positive prick or patch test for cow's milk
- •Control group: male or female, age before 6 month or within 12 and 18 month, eating cow's milk every day
Exclusion Criteria
- •immunodeficiency syndrome, lactose intolerance Control group: other food allergy, atopic dermatitis.
Outcomes
Primary Outcomes
Not specified
Study Sites (1)
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