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Clinical Trials/NCT00298376
NCT00298376UnknownNot Applicable

Oral Tolerance in Cow's Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora

Hospices Civils de Lyon1 site in 1 country50 target enrollmentStarted: March 2006Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Enrollment
50
Locations
1
Study OverviewStudy DesignEligibility CriteriaInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

This study aims to determine if there is a link between cow's milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others.

Cow's milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge.

Number and function of regulatory T cells and microflora composition are measured at the same time.

Allergic infants are compared to age matched control group.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Prospective

Eligibility Criteria

Ages
1 Month to 15 Months (Child)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •male or female, age before 6 month, cow's milk allergy with positive prick or patch test for cow's milk
  • •Control group: male or female, age before 6 month or within 12 and 18 month, eating cow's milk every day

Exclusion Criteria

  • •immunodeficiency syndrome, lactose intolerance Control group: other food allergy, atopic dermatitis.

Investigators

Sponsor Class
Other

Study Sites (1)

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