Diaphragmatic Function in Ventilated Patients
Completed
- Conditions
- Critically Ill
- Registration Number
- NCT00786526
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called ventilator-induced diaphragmatic dysfunction (VIDD).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 55
Inclusion Criteria
- Invasive mechanical ventilation (tracheally intubated or tracheotomized) less than 48h.·
- Duration of mechanical ventilation for at least 72h.·
- Subject itself or its next of kin has given written informed consent
Exclusion Criteria
- Patient is less than 18 years or more than 85 years of age·
- The attending physician refuses to allow enrollment·
- The patient refuses informed consent
- Next of kin is unavailable or refuses informed consent·
- Pregnant or breast-feeding female.
- A pregnancy test will be performed in all female patients less than 60 years of age.·
- Any contraindication to use cervical magnetic stimulation (mechanical cardiac assist device ...).·
- Presence or suspicion of prior diaphragm injury or chronic disease·
- Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Respiratory function parameters 6 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Service de Pneumologie et Réanimation
🇫🇷Groupe Hospitalier La Pitié-Salpêtrière-Paris, Paris, France
Department of Anesthesia and Critical Care (DAR B)
🇫🇷Saint-Eloi University Hospital of Montpellier, Montpellier, France