跳至主要内容
临床试验/NCT07695129
NCT07695129尚未招募不适用

Incidence and Predictors of Hemorrhagic Shock in Patients With Long Bone Fractures Presenting to the Emergency Department

Sohag University1 个研究点 分布在 1 个国家目标入组 250 人开始时间: 2026年7月25日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
250
试验地点
1
主要终点
Incidence of hemorrhagic shock

研究概览

简要总结

The goal of this observational study is to learn about the incidence and predators of hemorrhagic shock in patients with Long bone and pelvic fractures .The main question it aims to answer is:

In which bone fracture the prediction and detection of hemorrhagic shock should be in consideration for emergency management in polytrauma patients

详细描述

Trauma remains a leading cause of mortality worldwide, particularly among young adults, with hemorrhage accounting for a significant proportion of early preventable deaths . Hemorrhagic shock is a form of hypovolemic shock resulting from acute blood loss leading to inadequate tissue perfusion and oxygen delivery to meet cellular metabolic demands.

hemorrhagic shock occurs when systolic blood pressure (SBP) < 90 mmHg , Shock index ≥ 0.9 , serum lactate level ≥ 2 mmol/L or need for massive transfusion .

hemorrhagic shock is a critical complication of traumatic injuries associated with high morbidity and mortality if not promptly recognized and managed. Among traumatic injuries, fractures of long bones and the pelvis are particularly important due to their potential for substantial internal blood loss.

The Shock Index is calculated as:

Shock Index (SI) = Heart Rate (HR) ÷ Systolic Blood Pressure (SBP) Normal SI: 0.5 - 0.7 Early concern SI: ≥ 0.9 Indicative of hemorrhagic shock SI ≥ 1.0 . Long bone fractures, especially femoral fractures, can result in significant hemorrhage due to disruption of intramedullary vessels and surrounding soft tissues [4]. When multiple long bones are involved, the cumulative blood loss may be considerable and can contribute to the development of hypovolemic shock. Pelvic fractures, however, are even more concerning, as they are often associated with high-energy trauma and complex vascular injuries. The pelvis contains extensive venous plexuses and major arterial branches, making it a major source of life-threatening hemorrhage. It is estimated that venous bleeding accounts for approximately 80% of hemorrhage in pelvic fractures, primarily from the presacral and prevesical venous plexuses .

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients aged between 18 and 65 years
  • Presentation with radiologically confirmed:
  • Long bone fractures (femur, tibia, fibula, humerus, radius, ulna) and/or
  • Pelvic fractures
  • Presentation within 24 hours of injury

排除标准

  • Penetrating trauma to the abdomen and/or the chest.
  • Known bleeding disorders.
  • Patients on anticoagulants.
  • Major external hemorrhage requiring immediate surgical control
  • Isolated minor fractures (e.g., bones of hands or feet).
  • Dead on arrival

结局指标

主要结局

Incidence of hemorrhagic shock

时间窗: 1 hour ,2 hours , 4 hours and 6 hours

Shock index ≥ .9 Systolic blood pressure measurement \< 90mmHg

次要结局

  • Blood transfusion requirements(1st hour)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Yehia Zakaria Elsayed

Resident

Sohag University

研究点 (1)

Loading locations...

相似试验