Detection of Microplastics in Cardiac Surgery Patients: Its Metabolic Pathways and Toxic Effects
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 40
- Primary Endpoint
- Detection of microplastics in human heart tissue and the blood
Study Overview
Brief Summary
The exponential growth in plastic production/use translates into a parallel increase in environmental plastic waste, which is constantly degraded into microplastics and nanoplastics. Information on the effects of microplastics on human health is still preliminary.
Cardiac surgery patients is a population high exposed to plastics. This observational study will obtain biological samples of cardiac surgery patients as a reference and vulnerable group of individuals highly exposed to microplastics and potentially more susceptible.
The objective of this research is to be able to detect microplastics on blood and operation samples of cardiac surgery patients as well as their potential genotoxic and immunological damage.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age ≥18 years
- •Elective cardiac surgery
Exclusion Criteria
- •Emergency surgery or limited-term surgery
- •Previous cardiac surgery
- •Previous severe liver disease
- •Pregnant or planning to become pregnant
- •Have a malignant tumor
Outcomes
Primary Outcomes
Detection of microplastics in human heart tissue and the blood
Time Frame: perioperative: preoperative and pro-/postoperative blood and intraoperative heart tissue
Detection of microplastics in human heart tissue and the blood undergoing cardiac surgery
Secondary Outcomes
No secondary outcomes reported
Investigators
Kun Hua
Deputy Chief Surgeon
Beijing Anzhen Hospital