Assessment of medical treatment of diabetes on comorbid diastolic let-ventricular dysfunction observed by cardiac MRI in diabetic patients
Phase 2
Recruiting
- Conditions
- Heart failure with diastolic dysfunction and comorbid diabetes.
- Registration Number
- JPRN-UMIN000012209
- Lead Sponsor
- Cardiology, Nagoya University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
MACE within 3 months LVEF<50% Comorbid atrial fibrillation MR at more than moderate grade Patients taking DPP4i or GLP-1 analog ESRD or HD patient T1DM Malignancy within 5 years Uncontrolled arrhythmia Encontralled hypertension Expecting hospitalization within 6 months Insulin treatment Indication of cardiac surgery liver injury Autoimmune disease Pulmonary fibrosis Unstable AP or coronary spastic angina ASO (>Fontaine grade II) Contraindication for MRI Drug allergy to sitagliptin and any antidiabetic drug.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in LV early filling by use of CMR.
- Secondary Outcome Measures
Name Time Method MACE incidence of hospitalization by heart failure Changes in E/e' Changes in NT-proBNP Changes in endothelial function Changes in circulating DPP4 activity and biomarkers