Yorkshire screening of urine trial (YORKSURe)
- Conditions
- Bladder cancerCancerMalignant neoplasm of bladder
- Registration Number
- ISRCTN34273159
- Lead Sponsor
- niversity of Sheffield
- Brief Summary
2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37678944/ (added 08/09/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 1311
Cohort 1:
1. Men and women
2. Aged 55 – 80 years
3. Participants already enrolled within the YLST
4. Registered with a GP within the Leeds CCG area
5. Consented to contact from other research teams at the second YLST Lung Health Check visit
Cohort 2:
1. Men aged 65-79 years
2. Registered with a GP Practice identified as being in a region with a high bladder cancer mortality risk
Cohort 3:
1. Men and women aged 65-79 years referred to a recruiting urological department under the 2WW pathway for the investigation of haematuria (to include cystoscopy and urinary tract ultrasound, ± CT urogram)
Current exclusion criteria as of 15/07/2022:
Cohort 1:
1. Unable to/did not consent to contact from other research teams
2. Insufficient capacity to give consent to take part in the research as determined by the investigator/person taking consent for those that attend an Early Detection Clinic appointment.
Cohort 2:
1. National Data Opt-outs
2. Ever diagnosis of bladder or kidney cancer
3. Diagnosis with any other cancer within the past 5 years (except non-malignant skin cancer)
4. Insufficient capacity to give consent to take part in the research, defined as the presence of the following conditions coded in GP records:
4.1. Dementia
4.2. Alzheimer’s disease
4.3. Parkinson’s disease
or as determined by the investigator/person taking consent for those that attend an Early Detection Clinic appointment
Cohort 3:
1. Unable to provide written informed consent
2. Insufficient capacity to give consent to take part in the research, defined as the presence of the following conditions in medical notes:
2.1. Dementia
2.2. Alzheimer’s disease
2.3. Parkinson’s disease
or as determined by the investigator/person taking consent at the 2WW appointment
3. Evidence in patient medical record of historic dissent to use of data in research
4. Participant has opted out of data use via the National Data Opt Out
Previous exclusion criteria:
Cohort 1:
1. Unable to/did not consent to contact from other research teams
2. Insufficient capacity to give consent to take part in the research as determined by the investigator/person taking consent for those that attend an Early Detection Clinic appointment.
Cohort 2:
1. National Data Opt-outs
2. Ever diagnosis of bladder or kidney cancer
3. Diagnosis with any other cancer within the past 5 years (except non-malignant skin cancer)
4. Insufficient capacity to give consent to take part in the research, defined as the presence of the following conditions coded in GP records:
4.1. Dementia
4.2. Alzheimer’s disease
4.3. Parkinson’s disease
or as determined by the investigator/person taking consent for those that attend an Early Detection Clinic appointment
Cohort 3:
1. Unable to provide written informed consent
2. Insufficient capacity to give consent to take part in the research, defined as the presence of the following conditions in medical notes:
2.1. Dementia
2.2. Alzheimer’s disease
2.3. Parkinson’s disease
or as determined by the investigator/person taking consent at the 2WW appointment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method