Multicenter Validation of the PREDICT Score for Prediction of Local Recurrence After Total Mesorectal Excision of Rectal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 262
- 试验地点
- 1
- 主要终点
- Specificity of PREDICT score
研究概览
简要总结
Even after adequate TME with grade III mesorectal grading, local recurrence remains a possible event. Several studies investigated different parameters and assessed their predictive power in regards to local recurrence after TME. These parameters included a variety of patient-related, tumor-related, and treatment-related factors. A recent meta-analysis reviewed the current literature for the predictors of local recurrence after TME for rectal cancer and developed a prognostic scoring system, the PREDICT score.
The present study aimed to validate the PREDICT scoring system by applying it to a prospective cohort of patients with rectal cancer who underwent curative TME in three
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients of either sex with non-metastatic low or middle rectal cancer who underwent elective TME with curative intent
排除标准
- •Patients with recurrent or metastatic rectal cancer at the time of presentation
- •Patients with synchronous colon cancer
- •Patients with missing data on the outcome of TME.
结局指标
主要结局
Specificity of PREDICT score
时间窗: 36 months after surgery
The ability of the score to predict patients who did not experience recurrence after TME
Sensitivity of PREDICT score
时间窗: 36 months after surgery
The ability of the score to predict actual cases of recurrence after TME
次要结局
未报告次要终点
研究者
Sameh Emile
Associate professor of surgery
Mansoura University