NCT00379730已完成1 期
A Randomized, Double-blind Study of Treatment With a Known Anti-inflammatory (Prednisolone) to Evaluate Novel Endpoints in Patients With Chronic Obstructive Pulmonary Disease (COPD)
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 6
- 主要终点
- lung function tests using a system called Impulse oscillometry (IOS). CT scans to measure the thickness of the tubes in the lungs Blood, sputum and breath samples to measure chemical products in the lungs and body that relate to COPD
研究概览
简要总结
Prednisolone will be used as a model medication to identify new clinical outcomes for future evaluation of new therapies in short-term studies (up to 4 weeks) in patients with Chronic Obstructive Pulmonary Disease (COPD).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •An established clinical history of COPD
- •Evidence of bronchitis
- •Current or ex-smoker
排除标准
- •COPD exacerbation requiring steroid and/or antibiotics in the last month
- •Taking oral or inhaled steroids for more than 14 days in the last 6 months
- •Unable to withhold salbutamol/albuterol for a 6 hour period
- •History of alcohol, substance or drug abuse within the last year.
- •Other significant medical condition e.g. diabetes
- •Cancer that has not been in complete remission for at least 5 years
- •As a result of the medical interview, physical examination or screening investigations, that the doctor considers the subject unfit for the study.
结局指标
主要结局
lung function tests using a system called Impulse oscillometry (IOS). CT scans to measure the thickness of the tubes in the lungs Blood, sputum and breath samples to measure chemical products in the lungs and body that relate to COPD
次要结局
- Traditional lung function tests & Symptom Questionnaires
研究者
研究点 (6)
Loading locations...
相似试验
已完成
2 期
Efficacy of Methylprednisolone for Hantavirus Cardiopulmonary SyndromeHantavirus InfectionsNCT00128180University of New Mexico66
招募中
2 期
Methylprednisolone in Patients with Cognitive Deficits in Post-COVID-19 Syndrome (PCS)Post-COVID-19 SyndromeNCT05986422Charite University, Berlin, Germany418
已完成
4 期
Medical Polypectomy and Predictors of ResponseNasal PolypsNCT00788749University of Dundee60
终止
2 期
Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated HemangiomasHemangiomaNCT00555464Medical College of Wisconsin8
暂停
2 期
Prednisone for Decompensated Congestive Heart FailureHeart Failure, CongestiveNCT00369044Hebei Medical University60