Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Comparison of Oxidative stress markers in patients with colorectal cancer and controls
研究概览
简要总结
Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal cancer undergo surgical treatment (preoperatively during the intervention and postoperatively) and controls.
详细描述
Study of the impact of surgery on Lipid peroxidation, Protein peroxidation, damage by nitrogens, and RNA peroxidation, in patients undergo surgical resection for colorectal cancer and compared with controls, and validation of the responsiveness of oxidative stress markers on surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 25 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with colorectal cancer
排除标准
- •Metastatic Disease
- •Acute bowel obstruction
- •Acute bowel perforation
- •Chronic Systemic or Autoimmune Diseases
- •Alcohol consumers
研究组 & 干预措施
Surgery for colorectal cancer
Colorectal cancer patients
干预措施: Surgery for colorectal cancer (Procedure)
Controls
Controls
结局指标
主要结局
Comparison of Oxidative stress markers in patients with colorectal cancer and controls
时间窗: up to 2 years
Oxidative stress markers variation (8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG) during and after surgery for colorectal cancer, and compare with controls
次要结局
- Validation of oxidative stress markers in patients with colorectal cancer undergo surgical resection(up to 2 years)
研究者
E.Tsimoyiannis
Head of Department of Surgery, G.Hatzikosta General Hospital
G. Hatzikosta General Hospital