Investigating Myocardial Remodelling in the Failing Human Heart
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Oslo University Hospital
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- MRI functional parameters including Left Ventricular Ejection Fraction and Global Longitudinal Strain
- Status
- Recruiting
- Last Updated
- 9 months ago
Overview
Brief Summary
Despite improvements in therapy, heart failure is a disease with high mortality and accelerating prevalence. To improve patient care, it is necessary to better understand the features and underlying mechanisms of myocardial remodeling; how it manifests in vivo and its underlying cellular and extracellular changes. The RELAX study will offer insight into myocardial remodeling, by comprehensively assessing function and structure of failing human hearts, and investigate its underlying cellular and extracellular changes.
Investigators
Ivar Sjaastad
Professor
Oslo University Hospital
Eligibility Criteria
Inclusion Criteria
- •Eligible for heart transplantation
- •Willingness to participate in the present study and ability to understand and sign the written informed consent
Exclusion Criteria
- •Patients under the age of 18.
Outcomes
Primary Outcomes
MRI functional parameters including Left Ventricular Ejection Fraction and Global Longitudinal Strain
Time Frame: 1 years
Measurement of myocardial function by in-vivo methods. In-vivo myocardial function will be obtained by MRI and echocardiography. Measurements include LVEF and GLS.
MRI morphological parameters including LVEDV and LVESV.
Time Frame: 1 years
Measurement of myocardial morphology by in-vivo methods including MRI and ultrasound. The expected outcome in regards to morphology is varying degrees of geometrical abnormalities.
Myocardial stiffness measured by MRI and ex-vivo methods.
Time Frame: 1 year
Measurement of myocardial stiffness by in-vivo and ex-vivo methods. In-vivo myocardial stiffness will be measured by MRI. The expected outcome is varying degrees of stiffness in accordance with the underlying pathology as well as regionally in the heart. Ex-vivo methods include stiffness measurements by histology and protein analysis.