Effects of Transcutaneous Electrical acupoint Stimulation on Postoperative Delirium in cardiac valve replacement with Cardiopulmonary bypass patients

Phase 1

• Conditions: Postoperative Delirium

• Registration Number: ITMCTR1900002827
• Lead Sponsor: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Scheduled or limited for cardiac valve replacement with Cardiopulmonary acupuncture bypass patients aged 40 to 75 years old;
2. ASA I-III;
3. First thoracotomy;
4. Signed the informed consent form.

Exclusion Criteria

1. Suffered from the contraindication of TEAS including the local skin breakage, infection or planted with the electrophysiology device;
2. Unable to communicate and coordinate with the researcher, such as suffering from language comprehension deficits or mental diseases;
3. Certain/suspicious addiction with alcohol, analgenics or other drugs;
4. Preoperative placed intra-aortic balloon pump or ventricular assist device;
5. Severe dysfunction of liver or kidney meaning one of ALT, AST, ALP or TBIL is 2 times higher that normal or creatinine clearance < 30 ml/min or serum creatinine > 177umol/L;
6. Non-first-time thoracotomy;
7. Emergency surgery;
8. Participate in the other clinical trial 3 month before the enrollment.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Delirium scale (CAM-CR) score;

Secondary Outcome Measures

Name	Time	Method
the expression of interleukin 17a (IL-17A) in serum;the expression of S100 beta protein in serum;