The effect of soy milk on levothyroxine absorptio

Not Applicable

Recruiting

• Conditions: levothyroxine absortption; levothyroxine absorption; soy milk

• Registration Number: TCTR20191217002
• Lead Sponsor: Faculty of Medicine Ramathibodi Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-12-17
• Study Completion: 2020-08-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. Healthy volunteers
2. Aged 18-45 years
3. Written informed consent by volunteer

Exclusion Criteria

1. Adults with recent acute illness, cardiovascular disease/abnormal electrocardiogram, renal insufficiency (serum creatinine >1.5 mg/dL), abnormal liver function (AST and/or ALT > 3 times of upper normal limit)
2. Use of certain medications that interfere with levothyroxine absorption such as iron, calcium, proton pump inhibitor, sucralfate, aluminium hydroxide, cholestyramine; affect with levothyroxine metabolism such as phenytoin, carbamazepine, phenobarbital, rifampicin, tyrosine kinase inhibitor
3. Use of certain medications that alter thyroid hormone levels such as amiodaraone, lithium, interfereon-alpha, alemtuzumab, glucocorticoid, somatostatin
4. Use of certain medications that affect with thyroxine-binding globulin such as estrogen, raloxifene, tamoxifen, mitotane, fluorouracil, methadone, heroin, androgen, nicotinic acid
5. Adults who had intestinal absorption problem or history of gastric/intestinal surgery
6. Adults with allergy to soy and/or levothyroxine
7. Pregnant women/lactating women
8. Adults who has abnormal TSH concentrations
9. Denied to participate in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evothyroxine absorption test October 2019-September 2020 Area under the curve (AUC) of serum total T4 concentration

Secondary Outcome Measures

Name	Time	Method
analgesic usage until patient get operative fixation morphine dose requirement,complication until patient get operative fixation observe ex pressure sore peroneal nerve palsy