MR Elastography of the liver: Voxel-wise precision of viscoelasticity measurements at 3 Tesla MRI

• Conditions: chronic liver diseases; 10019654

• Registration Number: NL-OMON34573
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Patients:
**18 years of age
*Known chronic liver disease
*Not on treatment for liver disease during study period
*Written informed consent;Volunteers:
*No history of liver disease
*Written informed consent

Exclusion Criteria

Patients/Volunteers:
*Under 18 years of age
*Contra-indications for MRI scanning (use of standard MRI checklist, see document E4)
*Treatment for liver disease
*Use of medications known to have steatogenic effects on the liver: synthetic estrogens, corticosteroids, diltiazem, nifedipine, perhexilline, amiodarone, metformine, insulin, statins, rosglitazon, methotrexate, antiretroviral therapy, tamoxifen, tetracycline, valproate*
*Known hemochromatosis

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The voxel-wise variability in elasticity measurements for patients and healthy<br /><br>volunteers for:<br /><br>* Repeated measurements during one scanning session<br /><br>* Same-day reproducibility<br /><br>* Reproducibility with a 2-4 week interval</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>