Role of Simvastatin Microsponges in Treatment of Periodontitis
- Conditions
- Periodontitis
- Registration Number
- NCT04836078
- Lead Sponsor
- Assiut University
- Brief Summary
the aim of our study is to enhance the dissolution and subsequently the local penetration of the drug through the sulcus in addition to controlling the drug release so that, the drug could be potentially absorbed.
- Detailed Description
Patients will be divided randomly into three groups: Group (I);will be treated with subgingival debridement and subgengival injection of chitosan 2% gel containing a microsponges formulated (SV), Group (II); will be treated with subgingival debridement and subgingival injection of chitosan 2% gel containing free (SV) and Group (III); will be treated by subgingival debridement and placebo gel injected subgingivally. Pocket depth and clinical attachment loss bone gain were recorded preoperative and six months postoperative for all groups.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
- patients with chronic periodontitis with minimum two sites of pocket depth > 5 mm
- patients with normal lipid profile
- nonsmokers
- patients free from any systemic disorders
- committed patients to complete the treatment with follow-ups.
- patients with hyperlipidemia
- patients taking lipid lowering drugs
- smokers
- pregnant
- Lactating women women, patients with mental or psychological illness and medically compromised patients.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Pocket depth By the end of study after 6 months of 6 months Will be measured in millimetre
Clinical attachment loss By the end of study after 6 months of 6 months Will be measured in millimetre
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Assiut University
🇪🇬Assuit, Egypt
Assiut University🇪🇬Assuit, Egypt