The 'Train Smart' Study: Investigating the role of exercise training 'dose' on fitness, brain blood flow, brain volume, and cognitive function in middle-aged adults

Not Applicable

Completed

• Conditions: Cognitive decline and dementia; Vascular health; Physical inactivity; Neurological - Studies of the normal brain and nervous system; Cardiovascular - Normal development and function of the cardiovascular system; Mental Health - Studies of normal psychology, cognitive function and behaviour; Public Health - Health promotion/education; Neurological - Dementias

• Registration Number: ACTRN12621000144819
• Lead Sponsor: Victoria University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-02-12
• Study Completion: 2023-12-07
• Last Update Posted: 5 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Aged 45-65
- Able to participate in 36 exercise sessions over 12 weeks
- Normal cognition on screening
- BMI of 18 to 40
- Sign off from doctor to participate in the study

Exclusion Criteria

- Involved in regular exercise training in the previous 6 months
- Significant medical co-morbidities precluding participation in an exercise intervention (e.g., severe cardiac disease)
- Contraindications to have MRI
- Mild cognitive impairment on screening
- Recent diagnosis (14 days), close contact, or symptomatic of COVID-19
- Underweight or morbidly obese (BMI < 18 or > 40)
- History of any serious traumatic brain injury (e.g., ICU stay, rehab required, and/or a prolonged period of unconsciousness).
- High blood pressure at rest (over 160/100 mmHg)
- Current or ex-smoker (last 12 months)
- Any blood disorders or brain tumours
- Started any new medications (e.g., hormone replacement therapy) in the last 3 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified