Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment
Phase 1
Completed
- Conditions
- Periodontitis
- Interventions
- Other: Scaling and debridement only
- Registration Number
- NCT05583643
- Lead Sponsor
- Misr University for Science and Technology
- Brief Summary
Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss. Various topical anti-inflammatory drugs were used to treat inflammation in periodontitis. Introducing atorvastatin as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of targeting inflammation within the periodontal pockets.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- Systemically healthy patients
- Patients with moderate periodontitis
Exclusion Criteria
- Pregnant women
- Lactating women
- Patients with chronic diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Phase 1 therapy Scaling and debridement only - Phase 1 therapy with atorvastatin loaded into cubosomal in-situ gel Atorvastatin Calcium - Phase 1 therapy with atorvastatin loaded into in-situ gel Atorvastatin Calcium -
- Primary Outcome Measures
Name Time Method Probing depth 6 weeks Plaque index 6 weeks Bleeding index 6 weeks
- Secondary Outcome Measures
Name Time Method Assessment of transforming growth factor in gingival crevicular fluid 6 weeks
Trial Locations
- Locations (1)
Misr University for Science and Technology (MUST)
🇪🇬Giza, Egypt