UNC Childhood, Adolescent, and Young Adult Cancer Cohort
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pediatric Cancer
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Functional assessments
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
Purpose: This study aims to create a registry of childhood, adolescent, and young adult patients with cancer (<40 years-old at cancer diagnosis), entitled the 'UNC Childhood, Adolescent, and Young Adult Cancer Cohort' (UNC-CAYACC). This resource will serve to support cancer outcomes research among pediatric and young adult cancer patients with a primary focus on enrolling patients treated as adolescents or young adults (AYAs, 15-39 years).
Procedures: As appropriate for age, participants will complete physical and cognitive functional assessments; questionnaires to assess health-related quality of life and other patient-reported outcomes; will undergo body composition and anthropometric measurements; and will be asked to provide biospecimens for biobanking. Assessments will be collected (as possible) at diagnosis, during active treatment, following treatment completion, and annually in survivorship to assess outcomes throughout the treatment and survivorship trajectory. Sociodemographic and clinical information such as cancer treatment modalities and cumulative doses will be collected by medical record abstraction. Participants will be eligible to enroll at any time from diagnosis through survivorship. This registry will provide data to better understand the manifestations of accelerated aging and key contributing factors among children, adolescents, and young adults with cancer.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient ages 0-39 years at the time of cancer diagnosis (ages 1-39 years at enrollment) who are at any point in treatment and survivorship trajectory
- •English or Spanish speaking
Exclusion Criteria
- •Unwilling to sign informed consent
- •Speak a language other than English or Spanish.
Outcomes
Primary Outcomes
Functional assessments
Time Frame: Five years
Assess feasibility for completing repeated physical and cognitive functional assessments among young cancer survivors. These assessments include measures of physical and general frailty.
Registry development
Time Frame: Five years
Creation of a registry of pediatric and young adult patients with cancer treated within the University of North Carolina Health System
Secondary Outcomes
- Collection of sociodemographic, cancer, and treatment variables(Five years)
- Collection of patient-reported outcome measures(Five years)