Marijuana Use, Strength Training, and Alcohol Consumption (MUSTAC) Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Alcohol Demand: Omax
研究概览
简要总结
Self-medication of pain by consuming alcohol and marijuana is common. However, the research regarding pain as a determinant for alcohol and marijuana use has relied on laboratory pain induction paradigms with limited clinical relevance. The study will assess demand for alcohol and marijuana before and after delayed onset muscle soreness (DOMS) induction in co-users. This will provide a clinically relevant, but time-limited, model for the effects of musculoskeletal pain on demand.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 21 years;
- •English-speaking
- •Self-identify as White/Caucasian or Black/African American
- •Own a smartphone with cellular/data plan
- •Regularly co-use alcohol and smoked marijuana as indicated by scores of ≥3 on item 1 of the CUDIT-R and AUDIT.
- •Willing and able to give informed consent
排除标准
- •Participation in biceps-specific conditioning program in the past 6 months*
- •Self-reported wrist/hand, elbow, or shoulder pain the past 3 months
- •Chronic medical condition that may affect pain perception (e.g. diabetes, fibromyalgia, headaches)
- •Self-reported kidney dysfunction, muscle damage, or major psychiatric disorder
- •Medical marijuana prescription
- •Consumption of marijuana using only non-inhalational methods (e.g. edibles, tinctures, or cannabidiol oil)
- •Score of ≥ 10 on Patient Health Questionnaire-9 (moderate depression)
- •Women who are pregnant, trying to become pregnant, or breastfeeding
结局指标
主要结局
Alcohol Demand: Omax
时间窗: 48 hours after exercise
Changes in Omax, assessed using the Alcohol Purchase Task. Omax reflects the highest total amount in dollars that a participant would spend on alcohol-containing beverages. Values represent difference scores derived from log-transformed Omax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Omax
时间窗: 48 hours after exercise
Changes in Omax, assessed using the Marijuana Purchase Task. Omax reflects the highest total amount that a participant would spend on cannabis. Values represent difference scores derived from log-transformed Omax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Alcohol Demand: Intensity
时间窗: 48 hours after exercise
Changes in intensity of alcohol demand, assessed using the Alcohol Purchase Task. Intensity reflects the number of drinks that would hypothetically be consumed if they were free. Values represent difference scores derived from log-transformed number of drinks coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Alcohol Demand: Breakpoint
时间窗: 48 hours after exercise
Changes in breakpoint of alcohol demand, assessed using the Alcohol Purchase Task. Breakpoint indicates the drink price at which participants report no alcohol consumption. Values represent difference scores derived from breakpoint values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Alcohol Demand: Essential Value
时间窗: 48 hours after exercise
Changes in Essential Value, assessed using the Alcohol Purchase Task. Essential Value represents the reinforcing efficacy of alcohol, such that higher Essential Value indicates greater reinforcing efficacy. Values represent difference scores derived from Essential Values coded so that positive numbers indicate an increase in the demand index from baseline to follow-up.
Alcohol Demand: Pmax
时间窗: 48 hours after exercise
Changes in Pmax, assessed using the Alcohol Purchase Task. Pmax reflects the price point at which demand for alcohol becomes elastic (i.e., declines in response to increasing price). Values represent difference scores derived from log-transformed Pmax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Pmax
时间窗: 48 hours after exercise
Changes in Pmax, assessed using the Marijuana Purchase Task. Pmax reflects the price point at which demand for cannabis becomes elastic (i.e., declines in response to increasing price). Values represent difference scores derived from log-transformed Pmax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Breakpoint
时间窗: 48 hours after exercise
Changes in breakpoint of cannabis demand, assessed using the Marijuana Purchase Task. Breakpoint indicates the joint price at which participants report no cannabis consumption. Values represent difference scores derived from breakpoint values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Essential Value
时间窗: 48 hours after exercise
Changes in Essential Value, assessed using the Marijuana Purchase Task. Essential Value represents the reinforcing efficacy of cannabis, such that higher Essential Value indicates greater reinforcing efficacy. Values represent difference scores derived from Essential Values coded so that positive numbers indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Intensity
时间窗: 48 hours after exercise
Changes in intensity of cannabis demand, assessed using the Marijuana Purchase Task. Intensity reflects the number of joints that would hypothetically be consumed if they were free. Values represent difference scores derived from log-transformed intensity values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
次要结局
未报告次要终点