Marijuana Use, Strength Training, and Alcohol Consumption (MUSTAC) Study

Not Applicable

Completed

Conditions: Chronic Pain

Interventions: Behavioral: Eccentric Biceps Flexion
Behavioral: Concentric Biceps Flexion

Registration Number: NCT04791917

Lead Sponsor: University of Florida

Brief Summary: Self-medication of pain by consuming alcohol and marijuana is common. However, the research regarding pain as a determinant for alcohol and marijuana use has relied on laboratory pain induction paradigms with limited clinical relevance. The study will assess demand for alcohol and marijuana before and after delayed onset muscle soreness (DOMS) induction in co-users. This will provide a clinically relevant, but time-limited, model for the effects of musculoskeletal pain on demand.

Detailed Description: Not available

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 51

Inclusion Criteria

Age ≥ 21 years;
English-speaking
Self-identify as White/Caucasian or Black/African American
Own a smartphone with cellular/data plan
Regularly co-use alcohol and smoked marijuana as indicated by scores of ≥3 on item 1 of the CUDIT-R and AUDIT.
Willing and able to give informed consent

Exclusion Criteria

Participation in biceps-specific conditioning program in the past 6 months*
Self-reported wrist/hand, elbow, or shoulder pain the past 3 months
Chronic medical condition that may affect pain perception (e.g. diabetes, fibromyalgia, headaches)
Self-reported kidney dysfunction, muscle damage, or major psychiatric disorder
Medical marijuana prescription
Consumption of marijuana using only non-inhalational methods (e.g. edibles, tinctures, or cannabidiol oil)
Score of ≥ 10 on Patient Health Questionnaire-9 (moderate depression)
Women who are pregnant, trying to become pregnant, or breastfeeding

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Delayed Onset Muscle Soreness Induction	Eccentric Biceps Flexion	Participants will complete an exercise session designed to induce delayed onset muscle soreness in the biceps
Sham Delayed Onset Muscle Soreness Induction	Concentric Biceps Flexion	Participants will complete an exercise session that is unlikely to induce delayed onset muscle soreness in the biceps

Primary Outcome Measures

Name	Time	Method
Alcohol Demand: Omax	48 hours after exercise	Changes in Omax, assessed using the Alcohol Purchase Task. Omax reflects the highest total amount in dollars that a participant would spend on alcohol-containing beverages. Values represent difference scores derived from log-transformed Omax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Omax	48 hours after exercise	Changes in Omax, assessed using the Marijuana Purchase Task. Omax reflects the highest total amount that a participant would spend on cannabis. Values represent difference scores derived from log-transformed Omax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Alcohol Demand: Intensity	48 hours after exercise	Changes in intensity of alcohol demand, assessed using the Alcohol Purchase Task. Intensity reflects the number of drinks that would hypothetically be consumed if they were free. Values represent difference scores derived from log-transformed number of drinks coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Alcohol Demand: Breakpoint	48 hours after exercise	Changes in breakpoint of alcohol demand, assessed using the Alcohol Purchase Task. Breakpoint indicates the drink price at which participants report no alcohol consumption. Values represent difference scores derived from breakpoint values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Alcohol Demand: Essential Value	48 hours after exercise	Changes in Essential Value, assessed using the Alcohol Purchase Task. Essential Value represents the reinforcing efficacy of alcohol, such that higher Essential Value indicates greater reinforcing efficacy. Values represent difference scores derived from Essential Values coded so that positive numbers indicate an increase in the demand index from baseline to follow-up.
Alcohol Demand: Pmax	48 hours after exercise	Changes in Pmax, assessed using the Alcohol Purchase Task. Pmax reflects the price point at which demand for alcohol becomes elastic (i.e., declines in response to increasing price). Values represent difference scores derived from log-transformed Pmax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Pmax	48 hours after exercise	Changes in Pmax, assessed using the Marijuana Purchase Task. Pmax reflects the price point at which demand for cannabis becomes elastic (i.e., declines in response to increasing price). Values represent difference scores derived from log-transformed Pmax values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Breakpoint	48 hours after exercise	Changes in breakpoint of cannabis demand, assessed using the Marijuana Purchase Task. Breakpoint indicates the joint price at which participants report no cannabis consumption. Values represent difference scores derived from breakpoint values coded so that positive values indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Essential Value	48 hours after exercise	Changes in Essential Value, assessed using the Marijuana Purchase Task. Essential Value represents the reinforcing efficacy of cannabis, such that higher Essential Value indicates greater reinforcing efficacy. Values represent difference scores derived from Essential Values coded so that positive numbers indicate an increase in the demand index from baseline to follow-up.
Cannabis Demand: Intensity	48 hours after exercise	Changes in intensity of cannabis demand, assessed using the Marijuana Purchase Task. Intensity reflects the number of joints that would hypothetically be consumed if they were free. Values represent difference scores derived from log-transformed intensity values coded so that positive values indicate an increase in the demand index from baseline to follow-up.