Human Glioblastoma Multiforme (GBM) Circulating Tumor Cells (CTCs) as Early, Less Invasive Markers of Progression and Response
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Identification of Human GBM CD Antigen Signature.
研究概览
简要总结
The purpose of this study is to determine if tumor cells can be detected in the blood of patients diagnosed with a brain tumor.
详细描述
Despite aggressive therapies, Glioblastoma Multiforme (GBM) is rapidly fatal. GBMs are increasingly recognized for occasionally metastasizing through the peripheral blood to distant locations. This research study involves the detection and novel characterization of human GBM (hGBM) circulating tumor cells (CTCs) within the peripheral blood of brain tumor patients by identifying their unique cell surface antigen profile, determining an optimal isolation protocol, and quantitatively and qualitatively reporting the yield and characteristics.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 89 years of age
- •Weight of at least 110 pounds
- •Able to provide informed consent for self
排除标准
- •Patients with active malignant tumors other than GBM
结局指标
主要结局
Identification of Human GBM CD Antigen Signature.
时间窗: 3 Years
Already established and stored GBM cell lines will be screened for CD antigens to confirm that a selective cell surface antigen can be identified.
次要结局
- Identification & Isolation of Human GBM Cells in Seeded Normal Control Human Blood.(3 Years)
- Prospective Isolation of GBM Tumor Cells in GBM Patient Blood.(3 Years)
- Prospective Evaluation of the Routine Medical History of GBM Patients.(3 Years)