An investigation into the effect of neuromuscular electrical stimulation (NMES) and pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD)
- Conditions
- Chronic obstructive pulmonary disease (COPD)RespiratoryOther chronic obstructive pulmonary disease
- Registration Number
- ISRCTN46428072
- Lead Sponsor
- Record Provided by the NHSTCT Register - 2007 Update - Department of Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
1. Diagnosis of COPD
2. Declining functional capacity (Medical Research Council [MRC] grade 3 and above)
3. On optimal pharmacological treatment
4. Clinical stable (no exacerbation within 4 weeks of initial assessment and not taking antibiotics/oral steroids for an acute infection)
5. Smokers will be included
6. Patients receiving long-term oxygen therapy (LTOT) will be included
7. Evidence of nutritional depletion - body weight less than 90% of ideal body weight (IBW) and/or fat-free mass (FFM) less than 69% IBW (males) and 67% IBW (females)
8. Evidence of peripheral muscle weakness (quadriceps force less than 80% predicted and/or hand grip strength less than 80% predicted)
1. Unstable heart disease (and patients with pacemakers)
2. Untreated hypertension
3. Untreated hypothyroidism
4. Angina
5. Pregnancy
6. Arthritis (such that patient is unable to perform an exercise test and take part in an exercise training programme) or other mobility problems that will limit exercise capacity
7. Patients unable (or unwilling) to attend the hospital three times weekly for exercise training sessions
8. Patients unwilling to commit to lifestyle changes
9. Patients having an acute exacerbation of their disease within the previous 4 weeks
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method