Effect of Remote Ischemic Preconditioning on Brain Injury in Carotid Endarterectomy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Injuries
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- S100-beta biomarker
- Last Updated
- 9 years ago
Overview
Brief Summary
This is a randomized controlled trial designed to test an intervention (Remote ischemic preconditioning) in patients undergoing carotid endarterectomy (CEA).Remote ischemic preconditioning(RIPC) with transient upper limb ischemia/reperfusion is a novel, simple, cost-free,non-pharmacological and non-invasive strategy.The purpose of this study is to evaluate the effects of Remote Ischaemic Preconditioning on perioperative ischaemic injury in patients undergoing carotid endarterectomy compared to control intervention.The outcomes of interest include neurocognitive function,clinical outcomes,and biomarkers of brain injury.
Detailed Description
Remote ischemic preconditioning (RIPC) protocol will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a pressure 200mmHg
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing carotid endarterectomy
- •Patients aged 55 years to 80 years
Exclusion Criteria
- •Inability to give informed consent
- •Known Deep venous thrombosis (DVT) in arm
- •Pre-existing lymphedema or axillary node dissection both arms
- •Arteriovenous fistula or graft in both arms
- •Left ventricular ejection fraction less than 50%
- •Diagnosis of dementia, intellectual disability, or mental illness including depression, anxiety, or schizophrenia
Outcomes
Primary Outcomes
S100-beta biomarker
Time Frame: 48 hours post surgery
tested by ELISA
Secondary Outcomes
- Neuron specific enolase (NSE) biomarker(48 hours post surgery)
- Short - term cognitive function(1 day before surgery and 1 week post surgery)
- Sleep quality(1 week post surgery)