Impact of Gram stain results on initial treatment selection in patients with ventilator-associated pneumonia: a retrospective analysis of two treatment algorithms
- Conditions
- ventilator-associated penumonia
- Registration Number
- JPRN-UMIN000026457
- Lead Sponsor
- Osaka General Medical Centre
- Brief Summary
Antimicrobial choices proposed by the Guideline based algorithm and the Gram stain based algorithm were appropriate in 94.7% and 92.4% of cases, respectively. McNemar's test showed no significant difference in adequacy for the different strategies (p = 0.221). The Gram stain based algorithm proposed anti-methicillin-resistant Staphylococcus aureus agents in significantly fewer episodes than the Guideline based algorithm (41 (31.3%) versus 92 (70.2%), respectively (p < 0.001)). The Gram stain based algorithm also recommended antipseudomonal agents in significantly fewer episodes than the Guideline based algorithm (68 (51.9%) versus 92 (70.2%), respectively (p < 0.001)).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 219
Not provided
modified clinical pulmonary infection score (CPIS) less than 5. semi-quantitative growth of a respiratory pathogen using a respiratory sample was estimated to be less than 1+.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The coverage rates of initial antimicrobial therapies.
- Secondary Outcome Measures
Name Time Method The selected rates of anti-pseudomonal agents and anti-MRSA agents