Manipulating NMDA-dependent learning to alter nocebo effects: A pharmacological fMRI study on pain and itch. - Nocebo and Learning

niversiteit Leiden0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•A potential subject who meets any of the following exclusion criteria will be
•excluded from participation in this study:
•1. History of serious or chronic medical or psychiatric conditions
•2. History of chronic pain or itch conditions
•3. Experiencing pain or itch on the day of testing above the threshold of 1 out
•of 10 on the NRS
•4. Currently using antihistamines, analgesic medication, or itch-reducing
•medication (in the 24 hours prior to testing)
•5. Recent use of psychotropic drugs (including recreational drugs such as
•cannabis and psychotropic prescription-medication; in the past month)
•6. Currently being (or intending to become) pregnant, or currently breastfeeding
•7. Colour-blindness
•8. Body Mass Index under 16 or over 30
•9. Meeting any exclusion criteria for entering the MR scanner (e.g., permanent
•metal parts in the body)
•10. Having a too high threshold for pain (where high pain cannot be induced
•with temperatures lower than 49.5 °C) or not responding to histamine (no itch
•- A medical exam (carried out by a medical doctor) and a psychiatric screening
•will be completed per participant prior to participation. A medical backup team
•will be on call to further support the study medical doctor, who will monitor
•participants at all times during the study.

发起方

niversiteit Leiden