Study of the Use of Non-invasive Ventilation in Bronchial Dilatation Disease

Recruiting

• Conditions: Bronchial Dilatation Disease; Bronchectasie

• Registration Number: NCT06987461
• Lead Sponsor: Centre Hospitalier Intercommunal Creteil

Brief Summary

This is a medical record data collection study. The goal of this non-interventional and retrospective study is to describe the characteristics of the population currently being monitored for bronchial dilatation who have been treated with long-term NIV. This is a study based on data from medical records.

The assessment criteria will be :

* Epidemiological characteristics of the population with bronchial dilatation on long-term NIV

* Reasons for initiation of NIV

* NIV adjustment methods

Detailed Description

Non-invasive ventilation is a treatment sometimes used for severe severe bronchial dilatation, but to date there are no studies its efficacy.

The expected results in this context are :

* a description of the characteristics of patients with severe bronchial on non-invasive ventilation (NIV)

* a better understanding, during NIV management, of the settings used, the tolerance and effectiveness of NIV in reducing exacerbations, hospital admissions and patient mortality.

* move towards better patient management

Data will be extracted from patient medical records and the PMSI.

Study Timeline

• Study Start: 2025-01-06
• Study First Submitted: 2025-01-17
• Status Verified: 2025-05
• Study First Submitted QC: 2025-05-22
• Last Update Submitted: 2025-05-22
• Study First Posted: 2025-05-23
• Last Update Posted: 2025-05-23
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Patients over 18 years
• Predominant diagnosis of bronchiectatic disease, excluding cystic fibrosis, confirmed by computed tomography
• Introduction of long-term NIV at a given point in the patient's care

Exclusion Criteria

• Patient's opposition to participating in this study
• Cystic fibrosis
• Predominant diagnosis of COPD or asthma, traction bronchiectasis, bronchiectasis resulting from focal endobronchial lesion, sarcoidosis or active allergic bronchopulmonary aspergillosis.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
epidemiological characteristics of the population with bronchial dilation under long-term NIV	Through study completion, an average of 1 year
Reasons for placing under NIV	Through study completion, an average of 1 year
Non-invasive ventilation adjustment modalities	Through study completion, an average of 1 year

Secondary Outcome Measures

Name	Time	Method
Number of acute exacerbations (according to international recommendations) after initiation of NIV	Through study completion, an average of 1 year
Stabilization of respiratory functional tests evolution of FEV1 (%, slope) of PaCO2	Through study completion, an average of 1 year

Trial Locations

Locations (5)

Centre Hospitalier Intercommunal de Créteil; 🇫🇷 Créteil, France

Centre Hospitalier Universitaire Henri Mondor; 🇫🇷 Créteil, France

Centre Hospitalier Universitaire de Dijon; 🇫🇷 Dijon, France

Centre Hospitalier Universitaire de Rennes; 🇫🇷 Rennes, France

Centre Hospitalier Universitaire Toulouse; 🇫🇷 Toulouse, France