Endothelial Glycocalyx Status and Damage in Brain Death Organ Donors
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Markers of endothelial glycocalyx damage
研究概览
简要总结
The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients in critical condition declared as brain dead by clinical examination
排除标准
- 未提供
研究组 & 干预措施
Brain dead organ donors
Patients with clinically proven bain death were assigned to the paraclinical confirmatory investigation of the brain death and subsequently accepted into the transplantation program.
干预措施: Endothelial glycocalyx damage assessment (Diagnostic Test)
结局指标
主要结局
Markers of endothelial glycocalyx damage
时间窗: baseline at the time of inclusion
Levels of syndecan-1 in serum and urine
次要结局
未报告次要终点
研究者
David Astapenko, MD, PhD, MBA
Deputy Head for Science and Research
University Hospital Hradec Kralove