Contribution of SuPAR for Patients in a Situation of Uncertainty Downstream of Emergencies
- Conditions
- DiseaseEmergenciesIn-hospital Observation
- Interventions
- Other: blood supar measurement
- Registration Number
- NCT05214534
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
In this study, the investigators will investigate the relationship between the blood level of SuPAR at admission to the emergency department of the Clermont-Ferrand University Hospital, and the outcome of patients after their hospitalization in a short stay unit.
- Detailed Description
SuPAR (Soluble urokinase Plasminogen Activator Receptor) is a non-specific prognostic blood biomarker related to inflammation. An elevated SuPAR value reflects significant chronic inflammation and predicts a risk of negative outcome and even short-term mortality (intra-hospital, 30 days, 90 days). Conversely, a low SuPAR value is a strong indicator of good prognosis and low risk of readmission. It is therefore of interest to know a patient's SuPAR blood level to enable the clinician to decide whether the patient should be admitted or discharged. SuPAR has been shown to be the best prognostic marker associated with the presence and progression of disease and risk of mortality. The use of SuPAR in clinical routine adds significant complementary information to the standard Early Warning Score assessment and to the classical parameters such as CRP, PCT, Lactate, ALT, Bilirubin, and CBC in the pre-admission of acute patients.
Patients admitted to the emergency department will receive their usual management. We will test the added value of the SuPAR assay in the prognosis of patients' outcome at discharge.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 202
- Patient, male or female, over 18 years old
- Admitted to the emergency department of the Clermont-Ferrand University Hospital for a medical reason,
- Classified as FRENCH II or III by the nurse organizer of the reception management
- Necessity of clinical observation in the Short Term Hospitalization Unit for final orientation decision
- Requires a blood test upon arrival in the emergency department
- Able to give informed non-opposition to participate in the research.
- Affiliation to a Social Security system
- Patient under guardianship or curatorship
- Pregnant and breast feeding woman
- Patient admitted for psychiatric pathology
- Patient with a limitation of therapeutics
- Refusal to participate
- Patient hospitalized because of a particular social context
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Experimental blood supar measurement Retrospective analysis of the correlation between SuPAR measurement and patient outcome after hospitalization
- Primary Outcome Measures
Name Time Method Relationship between blood supar levels and patient outcome at discharge When the excepted 150 patients will be included, estimated 6 months Relation between blood supar levels measured and patient outcome at discharge evaluated as : return home = good evolution; hospitalization = bad evolution; admission to an intensive care unit or death = unfavorable evolution
- Secondary Outcome Measures
Name Time Method Cardiac frequency Hour 0 cardiac frequency will be evaluated when the patient arrives in the emergency service as part of the classical management
Respiratory rate Hour 0 respiratory rate will be evaluated when the patient arrives in the emergency service as part of the classical management
French triage Hour 0 French Emergency Nurses Classification in Hospitals (FRENCH) ranks priorities from 5 to 1 (from least urgent to most urgent) according to prognosis and complexity/severity of the medical condition
National Early Warning Score 2 (NEWS2) Hour 0 Score allowing the classification of the urgency of a patient. The minimum value is 0 and the maximum value is 20. Higher scores mean a worse outcome
Modified Early Warning Score (MEWS) Hour 0 Score allowing the classification of the urgency of a patient. The minimum value is 0 and the maximum value is 17. Higher scores mean a worse outcome
Blood CRP value Hour 0 the CRP value will be assessed during the blood test performed as part of the classical management when the patient arrives in the emergency room
Blood supar levels When the excepted 150 patients will be included, estimated 6 months the supar values are classifies into three categories : \< 3 ng/ml : supports the referral decision. the patient's general condition is good and the prognosis is high 3-6 ng/ml : presence of pathologies and comorbidity factors. readmissions and high mortality beyond 6 months \>6 ng/ml : requires special clinical attention, high risk of mortality
Temperature Hour 0 the temperature will be evaluated when the patient arrives in the emergency service as part of the classical management
Systolic blood pressure Hour 0 systolic blood pressure will be evaluated when the patient arrives in the emergency service as part of the classical management
Diastolic blood pressure Hour 0 diastolic blood pressure will be evaluated when the patient arrives in the emergency service as part of the classical management
Main diagnosis retained by the physician at the end of hospitalization Main diagnosis retained
Trial Locations
- Locations (1)
CHU clermont-ferrand
🇫🇷Clermont-Ferrand, France