Contribution of SuPAR for Patients in a Situation of Uncertainty Downstream of Emergencies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 202
- 试验地点
- 1
- 主要终点
- Relationship between blood supar levels and patient outcome at discharge
研究概览
简要总结
In this study, the investigators will investigate the relationship between the blood level of SuPAR at admission to the emergency department of the Clermont-Ferrand University Hospital, and the outcome of patients after their hospitalization in a short stay unit.
详细描述
SuPAR (Soluble urokinase Plasminogen Activator Receptor) is a non-specific prognostic blood biomarker related to inflammation. An elevated SuPAR value reflects significant chronic inflammation and predicts a risk of negative outcome and even short-term mortality (intra-hospital, 30 days, 90 days). Conversely, a low SuPAR value is a strong indicator of good prognosis and low risk of readmission. It is therefore of interest to know a patient's SuPAR blood level to enable the clinician to decide whether the patient should be admitted or discharged. SuPAR has been shown to be the best prognostic marker associated with the presence and progression of disease and risk of mortality. The use of SuPAR in clinical routine adds significant complementary information to the standard Early Warning Score assessment and to the classical parameters such as CRP, PCT, Lactate, ALT, Bilirubin, and CBC in the pre-admission of acute patients.
Patients admitted to the emergency department will receive their usual management. We will test the added value of the SuPAR assay in the prognosis of patients' outcome at discharge.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient, male or female, over 18 years old
- •Admitted to the emergency department of the Clermont-Ferrand University Hospital for a medical reason,
- •Classified as FRENCH II or III by the nurse organizer of the reception management
- •Necessity of clinical observation in the Short Term Hospitalization Unit for final orientation decision
- •Requires a blood test upon arrival in the emergency department
- •Able to give informed non-opposition to participate in the research.
- •Affiliation to a Social Security system
排除标准
- •Patient under guardianship or curatorship
- •Pregnant and breast feeding woman
- •Patient admitted for psychiatric pathology
- •Patient with a limitation of therapeutics
- •Refusal to participate
- •Patient hospitalized because of a particular social context
结局指标
主要结局
Relationship between blood supar levels and patient outcome at discharge
时间窗: When the excepted 150 patients will be included, estimated 6 months
Relation between blood supar levels measured and patient outcome at discharge evaluated as : return home = good evolution; hospitalization = bad evolution; admission to an intensive care unit or death = unfavorable evolution
次要结局
- Respiratory rate(Hour 0)
- French triage(Hour 0)
- Cardiac frequency(Hour 0)
- National Early Warning Score 2 (NEWS2)(Hour 0)
- Modified Early Warning Score (MEWS)(Hour 0)
- Blood CRP value(Hour 0)
- Blood supar levels(When the excepted 150 patients will be included, estimated 6 months)
- Temperature(Hour 0)
- Systolic blood pressure(Hour 0)
- Diastolic blood pressure(Hour 0)
- Main diagnosis retained by the physician(at the end of hospitalization)