The Role of Endothelin 1 as a Marker of Renal Impairment in Sickle Cell Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- renal affection in sickle cell patients
研究概览
简要总结
Sickle cell disease (SCD) refers to a group of hemoglobinopathies that include mutations in the gene encoding the beta subunit of hemoglobin. Within the umbrella of SCD, many subgroups exist, namely sickle cell anemia (SCA), hemoglobin SC disease (HbSC), and hemoglobin sickle-beta-thalassemia (beta-thalassemia positive or beta-thalassemia negative). Several other minor variants within the group of SCDs also, albeit not as common as the varieties mentioned above. It is essential to mention the sickle cell trait (HbAS), which carries a heterozygous mutation and seldom presents clinical signs or symptoms. Sickle cell anemia is the most common form of SCD
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patients fulfilling all the following criteria will be included:
- •Patients with sickle cell disease in the age range of 1-18years.
排除标准
- •Patients diagnosed to have coexistent renal disease before the study
结局指标
主要结局
renal affection in sickle cell patients
时间窗: 1 year
assessment of urinary endothelin 1 as a marker of renal impairment in sickle cell patients
次要结局
未报告次要终点
研究者
Esraa Anwar Qenawy
Resident-pediatric department-sohag hospital university
Sohag University