effect of oral clonidine on surgical blood loss
Phase 2
- Conditions
- blood loss during posterior spinal fusion surgery.Fracture of lumbar vertebra
- Registration Number
- IRCT201101205652N1
- Lead Sponsor
- Vice chancellor for research, Tehran (previous Iran) University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
inclusion criteria: 20-65yr old with American Society of Anesthesia (ASA) physical status of I-II candidated for posterior fusion of lumbar spine at 3 to 4 levels due to traumatic vertebral fracture
The exclusion criteria: significant underlying disease (hypertension, hepatic or renal disease, coagulation defects, diabetes mellitus), being under beta-blocker, calcium channel blocker, dioxin, tricyclic antidepressant, anticoagulant or clonidine treatment, drug or alcohol abuse.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Surgical blood loss. Timepoint: end of operation. Method of measurement: milliliter.
- Secondary Outcome Measures
Name Time Method Surgeon's satisfaction of a bloodless field. Timepoint: end of surgery. Method of measurement: surgeon's satisfaction scoring system.;Dose of remifentanil administered per hour to keep mean arterial pressure between 60 - 70 mmHg. Timepoint: end of operation/anesthesia. Method of measurement: milligram/hour.;Need for nitroglycerin added to remifentanil to keep mean arterial pressure between 60 - 70 mmHg. Timepoint: end of surgery. Method of measurement: number of petients who needed TNG in each group.;Occurance of severe/refractive bradycardia (as a complication of clonidine). Timepoint: when occured during operation/anesthesia. Method of measurement: number of patients.