Evaluation of effectivness of clomiphene plus Letrozole versus Clomiphene plus HMG in female infertility.

Phase 2

• Conditions: Female infertility.; Female infertility associated with anovulation

• Registration Number: IRCT2015090323621N3
• Lead Sponsor: Vice Chancellor for research of Iran Univercity of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

Women with history of infertility more over than one year and diagnosis of PCOS based on the revised 2003 consensus on diagnostic criteria; By clomiphene resistance that meant failure of ovulation after 100-150 mg CC for 5 days for 2-3 cycles and then resistant to letrozole 2.5 mg daily for 5 days for 2 cycles. Exclusion criteria: Women older than 40 years or younger than 20; fallopian tubes abnormality proved by hysterosalpingography; abnormal semen analysis for their partners according to the modified criteria of the World Health Organization; endocrine problem like hyper or hypo thyroidism, hyperprolactinemia; abnormal karyotype.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ovulation. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal ultrasound.;Pregnancy. Timepoint: After retard of mense. Method of measurement: Pregnancy test by missuring B-hCG.;The number of follicles. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal ultrasound.;Follicle size. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal ultrasound.;Endometrial thickness. Timepoint: Day 11 of the menstrual cycle. Method of measurement: Transvaginal ultrasound.

Secondary Outcome Measures

Name	Time	Method
Multiple pregnancies. Timepoint: 4-6 weeks after menstural delay. Method of measurement: pregnancy sonography.;Abortions under 20 weeks. Timepoint: after pegnancy. Method of measurement: pregnancy sonography.