Gene Expression Changes In Young and Geriatric Skin

Early Phase 1

Recruiting

• Conditions: UVB Phototherapy Burn; Insulin-like Growth Factor 1; Aging
• Interventions: Other: No Insulin-Lie Growth Factor 1; Drug: Insulin-Like Growth Factor 1

• Registration Number: NCT03932162
• Lead Sponsor: Wright State University

Brief Summary

This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-04-26
• Study First Submitted QC: 2019-04-26
• Study First Posted: 2019-04-30
• Study Start: 2019-09-06
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-05
• Last Update Posted: 2025-02-06
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Male/Female
• White skin (Fitzpatrick types I and II)
• Age 21-30 or 65 and older
• Able to comprehend procedures/risks

Exclusion Criteria

• Known photosensitivity
• Currently on photosensitizing medications
• Diabetes Mellitus
• History of abnormal scarring
• History of skin infections
• Known allergy to lidocaine local anesthetic
• Pregnancy or nursing
• Other serious health issues

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Young Adult	No Insulin-Lie Growth Factor 1	One small area of skin will undergo treatment with a small amount of UVB.
Geriatric Adult	Insulin-Like Growth Factor 1	Four small areas will undergo injection of a small amount of IGF-1 drug and two will undergo injections with saline. Then the injected areas will be treated with a small amount of UVB.

Primary Outcome Measures

Name	Time	Method
Change in expression genes involved in protecting skin cells from UVB damage in younger skin and geriatric skin injected with IGF-1 from baseline	2 Days	Expression genes involved in protecting skin cells from UVB damage, including p21, xeroderma pigmentosum (XPC), and polymerase eta, will be higher following UVB exposure in younger skin and geriatric skin injected with IGF-1 than in geriatric skin injected with saline as a control.

Trial Locations

Locations (1)

Wright State Physicians; 🇺🇸 Fairborn, Ohio, United States