ISRCTN32484878
已完成
未知
Combination Anti-Rheumatic Drugs in Early Rheumatoid Arthritis
Medical Research Council (MRC) (UK)0 个研究点目标入组 468 人2000年10月25日
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- Orthopaedics, rheumatology
- 发起方
- Medical Research Council (MRC) (UK)
- 入组人数
- 468
- 状态
- 已完成
- 最后更新
- 9年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •1\. RA by the 1987 criteria of the American College of Rheumatology
- •2\. Disease duration of less than 24 months
- •3\. The clinical need for treatment with a slow\-acting anti\-rheumatic drug (SAARD) as shown by evidence of active RA
- •4\. Patients must be willing and able to give informed consent
- •5\. Age greater than 18
排除标准
- •1\. Other forms of inflammatory arthritis (e.g. psoriatic arthritis, systemic lupus erythematosus)
- •2\. Current oral steroids for RA or other conditions (e.g. asthma)
- •3\. Contra\-indications to methotrexate
- •4\. Other serious medical disorders (e.g. hepatic failure, cardiac failure, current malignant disease)
- •5\. Females of child bearing potential who are not taking adequate contraceptive protection
- •6\. Contra\-indications to cyclosporin therapy
- •7\. Neutrophil count less than 1\.5 x 10^12 per decilitre or platelet count less than 100 x 10^12 per decilitre
- •8\. Abnormal liver function test (gamma glutamyl transferase \[gGT] greater than 3 x or aspartate aminotransferase \[AST]/alanine aminotransferase \[ALT] greater than 2 x upper limit of normal)
结局指标
主要结局
未指定
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