ISRCTN32484878已完成未知
Combination Anti-Rheumatic Drugs in Early Rheumatoid Arthritis
Medical Research Council (MRC) (UK)0 个研究点目标入组 468 人开始时间: 2000年10月25日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 468
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. RA by the 1987 criteria of the American College of Rheumatology
- •2. Disease duration of less than 24 months
- •3. The clinical need for treatment with a slow-acting anti-rheumatic drug (SAARD) as shown by evidence of active RA
- •4. Patients must be willing and able to give informed consent
- •5. Age greater than 18
排除标准
- •1. Other forms of inflammatory arthritis (e.g. psoriatic arthritis, systemic lupus erythematosus)
- •2. Current oral steroids for RA or other conditions (e.g. asthma)
- •3. Contra-indications to methotrexate
- •4. Other serious medical disorders (e.g. hepatic failure, cardiac failure, current malignant disease)
- •5. Females of child bearing potential who are not taking adequate contraceptive protection
- •6. Contra-indications to cyclosporin therapy
- •7. Neutrophil count less than 1.5 x 10^12 per decilitre or platelet count less than 100 x 10^12 per decilitre
- •8. Abnormal liver function test (gamma glutamyl transferase [gGT] greater than 3 x or aspartate aminotransferase [AST]/alanine aminotransferase [ALT] greater than 2 x upper limit of normal)
研究者
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